Twenty years' experience with myelomeningocele management at a single institution: lessons learned

Journal of Neurosurgery. Pediatrics
Robert KelloggStephanie Greene

Abstract

The authors reviewed 20 years' experience with the surgical management of open myelomeningocele in a well-defined retrospective cohort from a single large academic medical center. Their goal was to define the characteristics of a modern cohort of children with myelomeningocele to allow for evidence-based decision-making for the treatment of these patients. After IRB approval was obtained, the authors queried an operative database maintained by the Department of Neurological Surgery at Children's Hospital of Pittsburgh for patients who underwent closure of a myelomeningocele between 1995 and 2015. They identified 153 infants, and a retrospective chart review was performed. Eighty-eight percent of the patients required placement of a ventriculoperitoneal shunt, and 15% of these patients acquired shunt-related infections. Eighteen percent of patients underwent Chiari malformation type II (CM-II) decompression. Sixteen percent of patients underwent a tethered cord release. Three percent of patients died within the 1st year of life. Predictors of an early demise included poor Apgar scores, large head circumference, and need for early CM-II decompression. Functional motor outcome was slightly better than predicted by anatomical level...Continue Reading

References

Mar 1, 1992·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·P SteinbokB J Irwin
Aug 1, 1996·Developmental Medicine and Child Neurology·S J ConiglioJ E Ferguson
May 19, 2001·Pediatric Neurosurgery·R M BowmanJ A Ito
Jul 10, 2003·Intensive Care Medicine·Francisca García LizanaJean-Louis Vincent
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·I M HoldawayA W Stewart
Jun 24, 2004·Neurosurgical Focus·Kevin L Stevenson
May 17, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Sheree L BouletUNKNOWN National Birth Defects Prevention Network
Mar 28, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Robin M BowmanDavid G McLone
Apr 3, 2009·Journal of Neurosurgery. Pediatrics·Robin M BowmanDavid G McLone
Jul 3, 2009·Journal of Neurosurgery. Pediatrics·Wajd N Al-HolouCormac O Maher
Sep 30, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Samantha E ParkerUNKNOWN National Birth Defects Prevention Network
Oct 6, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Vivek A MehtaEdward S Ahn
Jul 5, 2011·Journal of Neurosurgery. Pediatrics·John R W KestleUNKNOWN Hydrocephalus Clinical Research Network
Feb 8, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·S Hassan A AkbariTae Sung Park
Sep 10, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Martina Messing-Jünger, Andreas Röhrig
Apr 8, 2014·Journal of Neurosurgery. Pediatrics·Varun R KshettryRobert J Weil
Nov 8, 2015·International Journal of Health Services : Planning, Administration, Evaluation·Patryk Perkowski, Leonard Rodberg
Nov 13, 2015·American Journal of Public Health·Callie A M AttaAmy Metcalfe
Jan 13, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Andre Broggin Dutra RodriguesWerther Brunow de Carvalho
Jun 1, 2016·American Journal of Obstetrics and Gynecology·Stephanie GreeneStephen P Emery
Oct 1, 2016·SAHARA J : Journal of Social Aspects of HIV/AIDS Research Alliance·L SteenkampM Beeforth
Mar 24, 2018·Journal of Neurosurgery. Pediatrics·Michael M McDowellStephanie Greene

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Citations

Oct 2, 2019·Neurosurgical Focus·Tatiana ProtzenkoSaint Clair Dos Santos Gomes
Jun 1, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Giuseppe TalamontiGiuseppe D'Aliberti
Jul 8, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·İsmail İştemenMehmet Babaoğlan
Apr 6, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Leopoldo Mandic Ferreira FurtadoTúlio Ramos Cavalcanti
Jul 29, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Tobias FingerMatthias Schulz
Sep 26, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·R CorroenneM S Cortes
Nov 1, 2020·International Journal of Molecular Sciences·Grégory PouriéCarine Bossenmeyer-Pourié
May 8, 2021·Journal of Neurosurgery. Pediatrics·Mark S DiasUNKNOWN National Spina Bifida Patient Registry Group

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