Individual differences in the dopaminergic system of the nucleus accumbens of rats have extensively been reported. These individual differences have frequently been used to explain individual differences in response to environmental and pharmacological challenges. Remarkably, only little attention is paid to the factors that underlie these individual differences. This review gives an overview of the studies that have been performed in our institute during the last 20 years to investigate individual differences in accumbal dopamine release. Data are summarised demonstrating that individual differences in accumbal dopamine release are due to individual differences in: the functional reactivity of the noradrenergic system, the accumbal concentration of vesicular monoamine transporters and tyrosine hydroxylase as well as in the quantal size of the presynaptic pools of dopamine. Our data are embedded in the available literature to create a model that illustrates the putative hardware giving rise to the individual-specific release of accumbal dopamine. An important role is contributed to individual differences in the reactivity of the: hypothalamic-pituitary-adrenal axes, the reactivity of second messenger systems as well in the amin...Continue Reading
Excitation-mediating and inhibition-mediating dopamine-receptors: a new concept towards a better understanding of electrophysiological, biochemical, pharmacological, functional and clinical data.
Possible role of cyclic nucleotides in regulation of noradrenaline release from rat pineal through presynaptic adrenoceptors
Biochemical mapping of the noradrenergic ventral bundle projection sites: evidence for a noradrenergic--dopaminergic interaction
Dopamine receptors: pharmacological and anatomical evidences indicate that two distinct dopamine receptor populations are present in rat striatum
Characterisation of the mechanisms for hyperactivity induction from the nucleus accumbens by phenylethylamine derivatives
Studies on the distinction between uptake inhibition and release of (3H)dopamine in rat brain tissue slices
Effects of antagonists upon locomotor stimulation induced by injection of dopamine and Noradrenaline into the nucleus accumbens of nialamide-pretreated rats
Effects of d- and l-amphetamine on habituation and sensitization of the acoustic startle response in rats.
A functional effect of dopamine in the nucleus accumbens and in some other dopamine-rich parts of the rat brain
ACTH1-39 inputs to mesocorticolimbic dopaminergic neurons: light and electron microscopic examination
Individual differences in basal and cocaine-stimulated extracellular dopamine in the nucleus accumbens using quantitative microdialysis
Differential role of mineralocorticoid and glucocorticoid receptors in the genesis of dexamphetamine-induced sensitization of mesolimbic, alpha 1 adrenergic receptors in the ventral striatum.
Differential modulation of (+)-amphetamine-induced rotation in unilateral substantia nigra-lesioned rats by alpha 1 as compared to alpha 2 agonists and antagonists
Effects of locus coeruleus lesions on the release of endogenous dopamine in the rat nucleus accumbens and caudate nucleus as determined by intracerebral microdialysis
Substance P-like immunoreactive neurons in the nucleus tractus solitarii of the rat send their axons to the nucleus accumbens
Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: resistance to differential rearing conditions.
Withdrawal of repeated cocaine decreases autoradiographic [3H]mazindol-labelling of dopamine transporter in rat nucleus accumbens
Evidence that dopamine in the nucleus accumbens is involved in the ability of rats to switch to cue-directed behaviours
Characterisation of methylphenidate and nomifensine induced dopamine release in rat striatum using in vivo brain microdialysis
Depletion of catecholamines in the brain of rats differentially affects stimulation of locomotor activity by caffeine, D-amphetamine, and methylphenidate.
Transduction of receptor signal into modulation of effector activity by G proteins: the first 20 years or so
The reserpine-sensitive dopamine pool mediates (+)-amphetamine-conditioned reward in the place preference paradigm.
Is the muscarinic receptor that mediates potentiation of dopamine release negatively coupled to the cyclic GMP system?
Cocaine: an in vivo microdialysis evaluation of its acute action on dopamine transmission in rat striatum
Individual differences in the sensitivity to serotonergic drugs: a pharmacobehavioural approach using rats selected on the basis of their response to novelty.
Repeated amphetamine administration in rats revealed consistency across days and a complete dissociation between locomotor and hypothalamic-pituitary-adrenal axis effects of the drug.
Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice.
Accumbal noradrenaline that contributes to the alpha-adrenoceptor-mediated release of dopamine from reserpine-sensitive storage vesicles in the nucleus accumbens is derived from alpha-methyl-para-tyrosine-sensitive pools.
Ontogenetic expression of dopamine-related transcription factors and tyrosine hydroxylase in prenatally stressed rats.
Synergistic, but not separate, stimulation of accumbal β1- and β2-adrenoceptors alters the accumbal dopamine efflux in freely moving rats
Working mechanism underlying the reduction of the behavioral and accumbal dopamine response to cocaine by α-1-adrenoceptor antagonists
Norepinephrine and dopamine modulate impulsivity on the five-choice serial reaction time task through opponent actions in the shell and core sub-regions of the nucleus accumbens.
Medications development for substance-use disorders: contextual influences (dis)incentivizing pharmaceutical-industry positioning
Repeated amphetamine injections alter behavior and induce a delayed behavioral sensitization modulated by reactivity to novelty: Similarities and differences with trauma consequences
Spiraling dopaminergic circuitry from the ventral striatum to dorsal striatum is an effective feed-forward loop
The α₁-, but not α₂-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats
Dopamine D₁-like receptors play only a minor role in the increase of striatal dopamine induced by striatally applied SKF38393
Peripheral nerve injury differentially regulates dopaminergic pathways in the nucleus accumbens of rats with either 'pain alone' or 'pain and disability'
Inter-individual differences in neurobiology as vulnerability factors for affective disorders: implications for psychopharmacology
The reboxetine-induced increase of accumbal dopamine efflux is inhibited by l-propranolol: a microdialysis study with freely moving rats
Changes in hyporesponsiveness to acute amphetamine and age differences in tyrosine hydroxylase immunoreactivity in the brain over adolescence in male and female rats
Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens.
Retracted: Terbium-sensitized fluorescence method for the determination of dopamine in biological fluids and tablet formulation
Withdrawal from extended-access cocaine self-administration results in dysregulated functional activity and altered locomotor activity in rats
Strictosidinic acid, isolated from Psychotria myriantha Mull. Arg. (Rubiaceae), decreases serotonin levels in rat hippocampus
Rats classified as low or high cocaine locomotor responders: a unique model involving striatal dopamine transporters that predicts cocaine addiction-like behaviors
Effect of Alkaloids Isolated from Phyllodium pulchellum on Monoamine Levels and Monoamine Oxidase Activity in Rat Brain
Locomotor response to novelty correlates with differences in number and morphology of hypothalamic tyrosine hydroxylase positive cells in rats
Individual differences in response to positive and negative stimuli: endocannabinoid-based insight on approach and avoidance behaviors
Noradrenaline-induced release of newly-synthesized accumbal dopamine: differential role of alpha- and beta-adrenoceptors
Nucleus accumbens and dopamine-mediated turning behavior of the rat: role of accumbal non-dopaminergic receptors
EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction
Reward modulation of cognitive function in adult attention-deficit/hyperactivity disorder: a pilot study on the role of striatal dopamine
Development of a voltammetric technique for monitoring brain dopamine metabolism: compensation for interference caused by DOPAC electrogenerated during homovanillic acid detection
Accumbal α-adrenoceptors, but not β-adrenoceptors, regulate behaviour that is mediated by reserpine-sensitive storage vesicles
Simultaneous activation of the α1A-, α1B- and α1D-adrenoceptor subtypes in the nucleus accumbens reduces accumbal dopamine efflux in freely moving rats
Extracellular Dopamine Levels in Nucleus Accumbens after Chronic Stress in Rats with Persistently High vs. Low 50-kHz Ultrasonic Vocalization Response.
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