Twenty years of unrelated donor hematopoietic cell transplantation for adult recipients facilitated by the National Marrow Donor Program

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Chatchada KaranesDennis L Confer

Abstract

For more than 20 years the National Marrow Donor Program has facilitated unrelated donor hematopoietic cell transplants for adult recipients. In this time period, the volunteer donor pool has expanded to nearly 12 million adult donors worldwide, improvements have occurred in the understanding and technology of HLA matching, there have been many changes in clinical practice and supportive care, and the more common graft source has shifted from bone marrow (BM) to peripheral blood stem cells (PBSCs). The percentage of older patients who are receiving unrelated donor transplants is increasing; currently over 1 in 10 adult transplant recipients is over the age of 60 years. Chronic myelogenous leukemia (CML) was previously the most common diagnosis for unrelated donor transplantation, but it now comprises less than 10% of transplants for adult recipients. Transplants for acute myelogenous leukemia (AML), acute lymphoblastic leukemia (ALL), non-Hodgkin lymphoma (NHL), and myelodysplastic syndromes (MDS) all outnumber CML. Treatment-related mortality (TRM) has declined significantly over the years, particularly in association with myeloablative transplant preparative regimens. Correspondingly, survival within each disease category has...Continue Reading

References

Dec 26, 2001·The New England Journal of Medicine·E W PetersdorfC Anasetti
Jul 15, 2004·Blood·Effie W PetersdorfJohn A Hansen
Jan 10, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Carolyn Katovich HurleyDennis L Confer
Jul 14, 2006·Transfusion·Jeffrey McCulloughJohn Hansen
Apr 21, 2007·Tissue Antigens·B E ShawE W Petersdorf
Nov 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mary EapenClaudio Anasetti
Jan 1, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stephanie J LeeDennis L Confer
Jun 11, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daniel WeisdorfJohn Klein

❮ Previous
Next ❯

Citations

Mar 23, 2010·Bone Marrow Transplantation·P A RamirezC G Brunstein
Aug 5, 2009·Current Opinion in Hematology·Tsila Zuckerman, Jacob M Rowe
Jan 15, 2010·Current Opinion in Hematology·Brian L McClune, Daniel J Weisdorf
Dec 17, 2008·Hematology·Catriona H Jamieson
Apr 21, 2012·Blood·Phillip Scheinberg, Neal S Young
Apr 5, 2013·PloS One·Steven RingquistMassimo Trucco
Nov 30, 2010·Therapeutic Delivery·Karim Y HelmyPranela Rameshwar
Sep 26, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kelsey BesseMark Albrecht
Jun 10, 2009·Expert Opinion on Drug Safety·Ulrike BacherAxel Rolf Zander
Apr 11, 2014·Annals of Medicine·Jesse D TroyWael Saber
Jul 24, 2012·Critical Reviews in Oncology/hematology·M SchlaakM von Bergwelt-Baildon
Jan 23, 2010·The Journal of Sexual Medicine·Richard SadovskyLuca Incrocci
Dec 3, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Navneet S MajhailJohn E Levine
Apr 3, 2010·Hematology/oncology Clinics of North America·Matthias Bartenstein, H Joachim Deeg
Dec 5, 2009·Best Practice & Research. Clinical Haematology·Mary M Horowitz
Jan 6, 2010·Journal of Gerontological Nursing·Marilyn J HammerDonna L Berry
Oct 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M J GandhiE K Jacob
Oct 15, 2009·Pediatric Blood & Cancer·Anthony N AudinoJeffrey D Hord
Sep 17, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·A John Barrett
Dec 14, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daniel WeisdorfJeffrey Miller
Mar 10, 2015·Protein & Cell·Hong Zhou, Rongzhen Xu
May 4, 2011·Journal of Experimental & Clinical Cancer Research : CR·Zhu XishanZhang Hongmei
Mar 17, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Deidre B PereiraVijay S Reddy
Aug 8, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mohamed A Kharfan-DabajaAmbuj Kumar
Aug 25, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nishitha ReddyBipin N Savani
Oct 14, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Elie RichaAndrew Artz
Jan 15, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ann A JakubowskiEsperanza B Papadopoulos
May 5, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Navneet S MajhailJ Douglas Rizzo
Sep 29, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·James L GajewskiRichard T Maziarz
Feb 10, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Elizabeth A MurphyNavneet S Mahjail

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Margaret L MacMillanNancy A Kernan
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
K K BallenNancy A Kernan
Bone Marrow Transplantation
K K Ballen, T R Spitzer
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Jeffrey R SchriberAlan K Leahigh
© 2022 Meta ULC. All rights reserved