Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia

International Journal of Molecular Sciences
Yuzuru ImaiNobutaka Hattori

Abstract

Mutations of coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2) and 10 (CHCHD10) have been found to be linked to Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and/or frontotemporal lobe dementia (FTD). CHCHD2 and CHCHD10 proteins, which are homologous proteins with 54% identity in amino acid sequence, belong to the mitochondrial coiled-coil-helix-coiled-coil-helix (CHCH) domain protein family. A series of studies reveals that these twin proteins form a multimodal complex, producing a variety of pathophysiology by the disease-causing variants of these proteins. In this review, we summarize the present knowledge about the physiological and pathological roles of twin proteins, CHCHD2 and CHCHD10, in neurodegenerative diseases.

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Citations

Nov 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Weiwei WanLei-Ke Zhang
Jan 8, 2020·Cell Death and Differentiation·Wei LiuChao Tong
May 5, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Karin KrupinskaMichela Zottini
Feb 5, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Yaling JiangLu Shen
Oct 31, 2020·Oxidative Medicine and Cellular Longevity·Amira Mohammed Ali, Hiroshi Kunugi
May 11, 2021·Frontiers in Aging Neuroscience·Teresa R KeeJung-A A Woo

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Methods Mentioned

BETA
exome sequencing
myristoylation

Software Mentioned

ClustalW

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