Twin displacive phase transitions in amino acid quasiracemates

The Journal of Physical Chemistry. B
Carl Henrik Görbitz, Pavel Karen

Abstract

Three quasiracemates, L-norleucine:D-methionine, L-norvaline:D-norleucine, and L-norvaline:D-methionine, were crystallized to see how they differ from regular racemates in terms of crystal structure (studied by single-crystal X-ray diffraction) and of thermally induced phase transitions (studied by differential scanning calorimetry). Two types of transitions are detected between 100 and 450 K and structurally characterized: (1) displacive transitions of the molecular bilayers that form the crystal and (2) continuous or discontinuous disordering transitions in the amino acid side chains. Uniquely for the quasiracemates, the displacive transition proceeds in two close steps as only one surface of each molecular bilayer slides at first, upon forming an intermediate phase, while the other surface follows at a slightly higher temperature. Altogether, 18 new single-crystal structure-refinement data sets are reported for these three quasiracemates.

References

Aug 6, 2000·Acta Crystallographica. Section B, Structural Science·B Dalhus, C H Görbitz
May 31, 2002·Acta Crystallographica. Section B, Structural Science·Frank H Allen
Feb 9, 2007·Journal of the American Chemical Society·Jamshed AnwarJohn Kendrick
Dec 25, 2007·Acta Crystallographica. Section A, Foundations of Crystallography·George M Sheldrick
May 23, 2009·Acta Crystallographica. Section B, Structural Science·Carl Henrik GörbitzRoberto Orlando
Jan 2, 2010·The Journal of Physical Chemistry. B·Petros ChatzigeorgiouKyriakos Viras
Mar 23, 2010·Acta Crystallographica. Section B, Structural Science·Carl Henrik Görbitz
May 13, 2010·Physical Chemistry Chemical Physics : PCCP·Carl Henrik GörbitzGraeme M Day
Feb 22, 2011·The Journal of Physical Chemistry. B·Carl Henrik Görbitz
Aug 8, 2012·The Journal of Physical Chemistry. B·Carl Henrik GörbitzVáclav Petříček
Oct 23, 2014·Angewandte Chemie·Franziska Stefanie IhlefeldtCarl Henrik Görbitz
Dec 9, 2014·Acta Crystallographica. Section E, Structure Reports Online·Carl Henrik GörbitzHåvard Kristiansen

❮ Previous
Next ❯

Citations

Jun 20, 2015·Acta Crystallographica. Section E, Crystallographic Communications·Carl Henrik GörbitzJon Borgersen
Jul 6, 2016·Acta Crystallographica. Section C, Structural Chemistry·Carl Henrik GörbitzBård Edgar Vestheim Sundsli
Apr 1, 2019·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·S G ArkhipovE V Boldyreva
Jun 1, 2019·Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials·Thomas Richard Welberry, Carl Henrik Görbitz
Mar 16, 2019·Crystal Growth & Design·Herma M CuppenCarl Henrik Görbitz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.