Twin pregnancy among women with pregestational type 1 or type 2 diabetes mellitus

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
N L Gonzalez GonzalezSpanish Diabetes and Pregnancy Study Group

Abstract

To assess the impact of twin versus singleton pregnancy on obstetric and perinatal outcomes among women with pregestational diabetes mellitus (DM). Multicenter retrospective cohort study of women with pregestational DM and twin or singleton pregnancy, conducted in Spain during 2005-2010. Each group included 63 women (type 1 DM, n=39; type 2 DM, n=24). Of 269 565 deliveries, 68 (0.025%) were twins of mothers with pregestational DM, with 28/63 (44.4%) conceptions achieved with assisted reproduction technology. Among women with type 1 DM, hypertensive complications were more common among those with twins than among controls (13% versus 3%, P=0.02); the rate of preterm birth was higher (69% versus 15%, P<0.001); and the rate of admission to the neonatal intensive care unit was higher (51% versus 21%, P=0.005). Twin pregnancy was an independent risk factor for adverse perinatal outcomes regardless of the type of diabetes. Twin pregnancy in women with either type of DM dramatically increased the risk of perinatal morbidity. In mothers with type 1 DM, twin pregnancy was more often associated with hypertensive complications than singleton pregnancy. Transfer of more than one embryo should be avoided if ART is needed in a woman with DM.

References

Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·M A BrownJ M Moutquin
Aug 15, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·A KerssenG H A Visser
Feb 9, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F FiguerasJ Gardosi
Dec 26, 2007·Acta Obstetricia Et Gynecologica Scandinavica·Nieves Luisa Gonzalez-GonzalezJosé L Bartha
Feb 15, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·R BellNorthern Diabetic Pregnancy Survey Steering Group
Oct 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Montserrat BalsellsR Corcoy
Jan 29, 2010·Diabetes Care·American Diabetes Association
Aug 6, 2010·Obstetrics and Gynecology Clinics of North America·Gabriella Pridjian
Aug 24, 2010·American Journal of Obstetrics and Gynecology·Suneet P ChauhanVincenzo Berghella
Feb 15, 2011·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Hyoin YangYoung Han Kim
Jun 18, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·Z C LuoW D Fraser
Jul 20, 2011·Journal of Perinatal Medicine·A Cristina Rossi, Vincenzo D'Addario
Sep 17, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·N L Gonzalez GonzalezJosé L Bartha
Feb 22, 2012·Clinical Obstetrics and Gynecology·Joaquin Santolaya, Revital Faro
Mar 1, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·A HolsteinP Kovacs
May 23, 2012·Fertility and Sterility·Christian BambergWolfgang Henrich
Jun 21, 2012·Seminars in Perinatology·Cande V Ananth, Suneet P Chauhan
Jul 16, 2013·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·N L González GonzálezE Domenech

Related Concepts

Diabetes, Autoimmune
Diabetes Mellitus, Non-Insulin-Dependent
Pregnancy in Diabetics
Pregnancy Outcome
Retrospective Studies
Assisted Reproductive Technologies
Pregnancy, Twin
Diabetes
Diabetes Mellitus
Diabetes Mellitus, Insulin-Dependent

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Related Papers

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
N IdrisD H McIntyre
Diabetic Medicine : a Journal of the British Diabetic Association
A García-PattersonR Corcoy
Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
S F WongH D McIntyre
© 2021 Meta ULC. All rights reserved