Twin screw wet granulation: the study of a continuous twin screw granulator using Positron Emission Particle Tracking (PEPT) technique

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Kai T LeeNeil A Rowson

Abstract

In this paper, Positron Emission Particle Tracking (PEPT) techniques are utilised to track the trajectory of single particles through the mixing and conveying zones of a Twin Screw Granulator (TSG). A TSG consisting of conveying zones and mixing zones is used in this study. The mixing zones are arranged with kneading discs at an angle of 30°, 60° or 90°. Experiments were carried out using different mixing configurations with various screw speed and total mass flow rate. The PEPT data obtained were then utilised to obtain the residence time distribution (RTD) and the Peclet number in an attempt to gain some insight into the mixing of the process. The fill level of the granulator was also estimated to study the mechanism of granulation. As might be expected, it was shown that the residence time of the granulation process increases with decreasing screw speed. It also increases with increasing angle of the arrangement of kneading blocks in the mixing zones, but will decreases when powder feed rate is increased. The fill level of the mixing zone in particular increases when the screw speed decreases or when powder feed rate increases. Furthermore, the fill level of the granulator will increase when the mixing zone configuration cha...Continue Reading

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Citations

Apr 29, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ashish KumarIngmar Nopens
Sep 23, 2014·International Journal of Pharmaceutics·Ashish KumarIngmar Nopens
Aug 16, 2014·International Journal of Pharmaceutics·Shen YuAgba D Salman
Jan 29, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tim Chan SeemAndy Ingram
Dec 29, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ashish KumarIngmar Nopens
Nov 5, 2015·International Journal of Pharmaceutics·Mohammed F SalehAgba D Salman
May 31, 2015·International Journal of Pharmaceutics·R MeierP Kleinebudde
Sep 22, 2015·International Journal of Pharmaceutics·Mohammed ManiruzzamanDennis Douroumis
Apr 15, 2015·International Journal of Pharmaceutics·Mohammed F SalehAgba D Salman
Sep 24, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ashish KumarIngmar Nopens
Feb 24, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ashish KumarIngmar Nopens
May 26, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R MeierP Kleinebudde
Jul 28, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tinne MonteyneThomas De Beer
Jun 3, 2018·Pharmaceutics·Sushma V LuteAgba D Salman
Jun 27, 2018·Pharmaceutical Research·Adrian SchmidtMarkus Krumme
Oct 12, 2020·International Journal of Pharmaceutics·Aquino L MundozahAgba D Salman
Jan 29, 2021·Drug Development and Industrial Pharmacy·Yi ZhangFeng Zhang
Mar 16, 2021·Journal of Drug Delivery Science and Technology·Sagar NaralaMichael A Repka
Apr 4, 2021·Pharmaceutics·Shashank Venkat MudduRohit Ramachandran
Aug 18, 2020·Journal of Pharmaceutical Sciences·Pallavi PawarRichard Elkes

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