Abstract
This study aimed to investigate the expression of Twist in gastric cancer tissues and its correlation between Twist and the epithelial-mesenchymal transition (EMT). By means of RT-PCR and Western blot, the mRNA and protein expressions of Twist, E-cadherin, and Vimentin in 61 gastric cancer tissues and adjacent normal tissues were detected. The positive rates of Twist, E-cadherin, and Vimentin mRNA expression in gastric cancer tissues were 73.9. 40.6, and 60.9 %, respectively; compared to the expression of these genes in adjacent normal tissues (2.9, 75.4, and 27.5 %), the differences were significant (p < 0.05). The E-cadherin protein expression level in gastric cancer tissues was significantly lower than that in the adjacent normal tissues (p < 0.05). After the transfection of Twist siRNA into the MKN45 cells, the protein expression of Twist was significantly reduced (p < 0.05), the protein expression of E-cadherin was significantly increased, and the number of cells that passed through the Transwell chamber was significantly lower than that in the non-transfected control group as well as the transfected control group (p < 0.05). Twist may be associated with the epithelial-mesenchymal transition in gastric cancer and the tumor...Continue Reading
References
Nov 14, 1997·Trends in Genetics : TIG·C S Rose, S Malcolm
May 8, 2002·Nature Reviews. Molecular Cell Biology·M Angela Nieto
Jul 20, 2002·The Lancet Infectious Diseases·Francois Gasse
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
Jun 24, 2004·Cell·Jing YangRobert A Weinberg
Aug 11, 2004·Nature Cell Biology·Pierre A Coulombe, Pauline Wong
Jan 28, 2005·Oncogene·Andreas EgerRoland Foisner
Oct 4, 2005·Optics Letters·Ailing Zhang, M S Demokan
Oct 19, 2005·Neoplasia : an International Journal for Oncology Research·Maria C EliasRobert C Rostomily
Oct 20, 2005·Deutsche medizinische Wochenschrift·S GrönkeE Erdmann
Oct 21, 2005·Chest·Leena TiittoRiitta Kaarteenaho-Wiik
Dec 13, 2005·Journal of Proteome Research·Andrzej K DrukierJasminka Godovac-Zimmermann
Jan 18, 2006·Cancer Letters·Li-Bing SongMu-Sheng Zeng
Feb 14, 2006·Journal of Cataract and Refractive Surgery·Gebtraud SchildAndreas Kruger
May 26, 2006·Nature Reviews. Cancer·Patrick Mehlen, Alain Puisieux
May 26, 2006·Nature·Gerhard Christofori
Jul 25, 2006·Oncogene·H L ChuaH Nakshatri
Jan 20, 2007·International Journal of Cancer. Journal International Du Cancer·Kenoki OhuchidaMasao Tanaka
Mar 3, 2007·Cancer Research·George Z ChengLu-Hai Wang
Mar 31, 2007·Histopathology·H-F YuenK-W Chan
Oct 2, 2007·Gynecologic Oncology·Hirohisa TsukamotoFumitaka Kikkawa
Jul 5, 2008·Cancer Cell·Stéphane AnsieauAlain Puisieux
Dec 3, 2008·Archives of Biochemistry and Biophysics·Dayami LopezW Bradford Carter
Apr 23, 2009·Cancer Research·Li QinJianming Xu
Dec 17, 2009·Cancer Metastasis Reviews·David J McConkeyColin Dinney
Dec 23, 2009·Journal of Experimental & Clinical Cancer Research : CR·Ken SasakiTakashi Aikou
Nov 23, 2010·Cell Cycle·Silvia CufíJavier A Menendez
Dec 21, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jin-Haeng ChungJae Cheol Lee
Jan 21, 2011·PloS One·Ma'in Y MaitahFazlul H Sarkar
Mar 12, 2011·Annals of Surgery·Muhammed Ashraf MemonBreda Memon
Citations
May 17, 2014·Annals of Surgical Oncology·Suguru YamadaYasuhiro Kodera
Jan 31, 2015·Molecular Medicine Reports·Jianwei ZhuXiancheng Liu
Jan 13, 2015·Molecular Medicine Reports·Mingdi ZhangZhiwei Quan
Aug 13, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ping XiaoRuirui Yang
Dec 15, 2015·Pharmacognosy Magazine·Hyun Soo ParkByung Joo Kim
Jun 30, 2015·Journal of Pharmacopuncture·Noo Ri HongByung Joo Kim
Feb 11, 2014·Carbohydrate Polymers·Cong LiJing-Shu Geng
Jan 21, 2015·Frontiers in Oncology·Ana Sofia Ribeiro, Joana Paredes
May 18, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Peyman EivazyMehdi Yousefi
Oct 8, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hai-Ting Liu, Peng Gao
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Pu Xia, Xiao-Yan Xu
Jan 15, 2014·Cancer Metastasis Reviews·Rhonda L BittingAndrew J Armstrong
Apr 23, 2016·Oncotarget·Yuehong CuiTianshu Liu
Sep 27, 2018·Oncology Letters·Danli YeQingling Zhang
Feb 14, 2013·International Journal of Oncology·Zhaohui ZhuHaipeng Wang
Jan 25, 2019·Oncology Letters·Junji KurashigeKoshi Mimori
Apr 20, 2019·Molecular Cancer·Min SuWenxiang Wang
Apr 10, 2020·International Journal of Molecular Sciences·Jacek BajPiero Portincasa
Apr 12, 2014·Oncotarget·Hee Jun ChoJiyun Yoo
Jul 6, 2017·Oncology Reports·Yebo GaoBaojin Hua
Apr 16, 2016·International Journal of Oncology·Cunen WuXi Zou
Mar 31, 2017·Oncology Letters·Xudong HuCaiyun Zhong