Twist may be associated with invasion and metastasis of hypoxic NSCLC cells

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Ling WeiXian-Rang Song

Abstract

Hypoxia promotes tumor invasion and metastasis via multiple mechanisms, including epithelial-mesenchymal transition (EMT). Twist, an EMT regulator, has been disclosed to associate with invasion and metastasis as well as poor prognosis of many malignancies. However, it remains undefined whether Twist is involved in invasion and metastasis of hypoxic non-small cell lung cancer (NSCLC). In this study, protein levels of Twist, hypoxia-inducible factor-1α (HIF-1α), and EMT markers (E-cadherin and vimentin) were examined by immunohistochemistry in 76 lung cancer tissues from NSCLC patients. Expression of Twist and its correlation with HIF-1α, E-cadherin, and vimentin were analyzed. Small interfering RNA (siRNA) against Twist was used to knockdown Twist expression in hypoxic NSCLC cells, A549 and NCI-H460. Cellular invasion and protein levels of Twist, E-cadherin, and vimentin were evaluated by matrigel invasion assay and Western blot, respectively. Our results showed that in clinical samples, there was a significant association between Twist expression and differentiation degree, lymph node metastasis, and TNM stage. Correlation analysis demonstrated that expression of Twist was negatively correlated with E-cadherin expression, but p...Continue Reading

References

Jul 19, 2005·Cancer Research·Erik W ThompsonDavid Tarin
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Jean Paul Thiery, Jonathan P Sleeman
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Terence K LeeSheung Tat Fan
May 22, 2007·Biochemical and Biophysical Research Communications·Zhou YangXiaoting Wu
Dec 8, 2007·Biochemical and Biophysical Research Communications·Farhad VesunaVenu Raman
Feb 26, 2008·Nature Cell Biology·Muh-Hwa YangKou-Juey Wu
Dec 4, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tao SunBao-Cun Sun
Nov 26, 2010·Pathology Oncology Research : POR·Guo-Qing RuZhong-Sheng Zhao
Aug 26, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Alimujiang WushouZhi-Yuan Zhang
Apr 30, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Wen-Shuang WangJian-Qing Hou
Apr 30, 2013·PloS One·Linping HuiXueshan Qiu
Jun 5, 2014·Molecular Cancer Research : MCR·Rosemarie Chirco D'AngeloHyeong-Reh Choi Kim
Mar 12, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kaize ZhongJian Zhao

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Citations

Jul 29, 2016·Antioxidants & Redox Signaling·Debashree BasudharLisa A Ridnour
May 31, 2018·Cancer Medicine·Camille EmprouMichèle Beau-Faller
Dec 11, 2019·International Journal of Molecular Sciences·Alexandru Andrei TirpeIoana Berindan-Neagoe
Mar 22, 2016·Biomarkers in Cancer·Kazushi Inoue, Elizabeth A Fry
Nov 24, 2019·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yadong WangHaiyan Yang
Dec 3, 2020·Frontiers in Oncology·Tianhao ZhuSibo Zhu
Jun 18, 2021·Frontiers in Oncology·Sumei YaoYihua Wang
Jul 25, 2021·Cancers·Julien AncelValérian Dormoy

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