Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells

Molecules and Cells
Han Seok KohSung Ho Jeon

Abstract

In the periphery, a galectin-1 receptor, CD7, plays crucial roles in galectin-1-mediated apoptosis of activated T-cells as well as progression of T-lymphoma. Previously, we demonstrated that NF-kappaB downregulated CD7 gene expression through the p38 MAPK pathway in developing immature thymocytes. However, its regulatory pathway is not well understood in functional mature T-cells. Here, we show that CD7 expression was downregulated by Twist2 in Jurkat cells, a human acute T-cell lymphoma cell line, and in EL4 cells, a mature murine T-cell lymphoma cell line. Furthermore, ectopic expression of Twist2 in Jurkat cells reduced galectin-1-induced apoptosis. While full-length Twist2 decreased CD7 promoter activity, a C-terminal deletion form of Twist2 reversed its inhibition, suggesting an important role of the C-terminus in CD7 regulation. In addition, CD7 expression was enhanced by histone deacetylase inhibitors such as trichostatin A and sodium butyrate, which indicates that Twist2 might be one of candidate factors involved in histone deacetylation. Based on these results, we conclude that upregulation of Twist2 increases the resistance to galectin-1-mediated-apoptosis, which may have significant implications for the progression o...Continue Reading

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Citations

Jul 23, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Md Asaduzzaman KhanJunjiang Fu
May 26, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dimitri SalameireMarie-Christine Jacob
Apr 25, 2013·World Journal of Gastroenterology : WJG·Hao YuJia-He Yang
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Sep 4, 2010·Developmental and Comparative Immunology·Dianchang ZhangTianfeng Su
Apr 21, 2012·Journal of Cutaneous Pathology·Meghali GoswamiXiao Ni
Sep 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yuebo GanAdam Bagg
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Apr 25, 2018·Journal of Biomedical Science·San-Chi ChenMuh-Hwa Yang
May 11, 2021·Autoimmunity Reviews·Wang-Dong XuAn-Fang Huang

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