Two amino acid substitutions in acetylcholinesterase associated with pirimicarb and organophosphorous insecticide resistance in the cotton aphid, Aphis gossypii Glover (Homoptera: Aphididae)

Insect Molecular Biology
S TodaY Kono

Abstract

The complete coding sequences of two acetylcholinesterase (AChE) genes, Ace1 (orthologous to Drosophila Ace) and Ace2 (paralogous to Ace), from the cotton aphid (Aphis gossypii) were identified and sequences from carbamate resistant and susceptible strains compared. No change in the amino acid sequences was found in Ace1, while two amino acid substitutions, Ser431Phe and Ala302Ser, were detected between resistant and susceptible strains in Ace2. The position of Ser431Phe corresponds to one of fourteen aromatic residues lining the active site gorge and is located in the acyl pocket. Ala302Ser is located at one of the three residues which form the oxyanion hole in the active site of AChE. The Ser431Phe and Ala302Ser substitutions may play a role in pirimicarb and organophosphate resistance, respectively.

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Citations

Jun 5, 2007·Genome Génome / Conseil National De Recherches Canada·Mao-hua ChenMing-jing Qu
Nov 30, 2010·Insect Biochemistry and Molecular Biology·Evdoxia G KakaniKostas D Mathiopoulos
Dec 27, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yiou PanXiwu Gao
Nov 26, 2008·Biochemical and Biophysical Research Communications·Xiaojing JiangZhaojun Han
Jul 16, 2008·Insect Biochemistry and Molecular Biology·E G KakaniK D Mathiopoulos
Dec 2, 2011·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Sibel BaşkurtVatan Taşkın
Nov 13, 2009·Pest Management Science·Jérôme CarlettoThierry Brévault
Jan 28, 2014·Insect Biochemistry and Molecular Biology·Yixi ZhangZewen Liu
Jun 6, 2015·Pesticide Biochemistry and Physiology·René FeyereisenThomas Van Leeuwen
Feb 14, 2007·Journal of Medical Entomology·Si-Woo LeeTakashi Tomita
Nov 20, 2008·Insect Molecular Biology·F NardiF Frati
Apr 11, 2006·Genome Génome / Conseil National De Recherches Canada·Maohua Chen, Zhaojun Han
Jan 1, 2014·Insects·Margaret C Hardy

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