PMID: 49055Jun 1, 1975Paper

Two antigenically distinct species of human interferon

Proceedings of the National Academy of Sciences of the United States of America
E A HavellJ Vilcek

Abstract

Rabbit antisera prepared against interferon produced in human fibroblast cell cultures stimulated with poly(1).poly(C) neutralized the activity of interferon preparations produced in various human fibroblast cultures timulated either with poly(1)poly)C) or with viruses. However, these antisera showed no detectable neutralizing activity against interferon produced in cultures of human leukocytes. On the other hand, most rabbit antisera against the human leukocyte interferon were active in neutralizing both homologous interferon and fibroblast interferons. A preparation of antiserum against leukocyte interferon, active against both leukocyte and fibroblast interferons, was shown by affinity chromatography to have two distinct antibody populations, one of which was specific for the fibroblast interferon. We conclude that the heterologous neutralizing activity of sera from rabbits immunized with leukocyte interferon is liekly to be due to the presence of two antigenic species of interferon. The major antigenic species of leukocyte interferon preparations (designated "Le") is distinct from huamn fibroblast interferon. The minor species of leukocyte interferon ("F") is either identical with, or closely related to, interferon produced...Continue Reading

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Citations

Nov 1, 1978·Biulleten' eksperimental'noĭ biologii i meditsiny·S V SkurkovichE I Eremkina
Jan 1, 1984·Archives of Virology·E A Havell, G L Spitalny
Jan 1, 1979·Archives of Virology·P Jameson, S E Grossberg
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Jun 26, 1992·Journal of Chromatography·Z ZhangJ C Janson
May 1, 1980·Molecular Immunology·M Wiranowska-StewartW E Stewart
Jan 1, 1981·Pharmacology & Therapeutics·V Bocci
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Jun 1, 1980·Gene·T TaniguchiM Muramatsu
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Dec 1, 2007·Nature Reviews. Drug Discovery·Ernest C BordenGeorge R Stark
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S PestkaJ Vilcek
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·K PauckerE Törmä
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P B Sehgal, I Tamm
Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·W E StewartK Cantell
Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·N B Raj, P M Pitha
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R L CavalieriS Pestka
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·P B SehgalI Tamm
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W E StewartM Wiranowska-Stewart
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P A Neighbour, B R Bloom
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Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R H PangJ Vilcek
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P B SehgalF H Ruddle
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·I C OliveiraJ Vilcek
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May 11, 1984·Nucleic Acids Research·J HiscottC Weissmann
Apr 1, 1979·European Journal of Clinical Investigation·W WeimarH Schellekens
Mar 4, 1977·Annals of the New York Academy of Sciences·S PestkaJ Vilcek

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