Two Are Better Than One: Dual Targeting of Riboswitches by Metabolite Analogs

Cell Chemical Biology
Stefanie Sandra KrajewskiJörgen Johansson

Abstract

In this issue of Cell Chemical Biology, Wang et al. (2017) examine the effect of the novel synthetic molecule ribocil-C and the natural compound roseoflavin in Gram-positive pathogens. In methicillin-resistant Staphylococcus aureus (MRSA), ribocil-C and roseoflavin target two autonomous riboswitches simultaneously, thereby inhibiting de novo synthesis and uptake of riboflavin.

References

Nov 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Wade C WinklerRonald R Breaker
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Sep 11, 2009·ACS Chemical Biology·Jane N KimRonald R Breaker
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Jul 20, 2016·Gene·Elnaz Mehdizadeh AghdamAbolfazl Barzegar

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Citations

Aug 28, 2019·Microbial Cell Factories·Rodrigo Mora-LugoMatthias Mack
Sep 8, 2021·Virulence·Junwen LeiZhangyong Song

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