PMID: 6105958Jul 1, 1980Paper

Two asparagine synthetases in Saccharomyces cerevisiae

European Journal of Biochemistry
F Ramos, J M Wiame

Abstract

In Saccharomyces cerevisiae L-asparagine auxotrophy, resulting from a lack of L-asparagine synthesis, needs simultaneous defects in two genes. This unusual situation is shown to result from the occurrence of two L-asparagine synthetases. The meaning of this duplication remains obscure. The properties of the two enzymes are remarkably similar: both have a molecular weight of 150,000 and they exhibit a slight repression and a similar inhibition by asparagine. Neither one is located in mitochondria and both are probably cytosolic. Their identification so far lies only in their behaviour on ion-exchange chromatography and in the encoding genes.

References

Mar 1, 1979·European Journal of Biochemistry·F Ramos, J M Wiame
Nov 1, 1977·European Journal of Biochemistry·C LegrainJ M Wiame
Jul 1, 1957·Biochimica Et Biophysica Acta·L GORINI, W K MAAS
Jan 1, 1961·Cold Spring Harbor Symposia on Quantitative Biology·E R STADTMAN de ROBICHON-SZULMAJSTER
Oct 1, 1959·Proceedings of the National Academy of Sciences of the United States of America·B N Ames, B Garry

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Citations

Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J RineR W Davis
Oct 6, 2005·Genome Research·Lars KuepferLars M Blank
Oct 27, 2018·PLoS Genetics·Shanshan ZhangJi-Long Liu
Nov 5, 2015·Nature Communications·Viswanathan A NagarajGovindarajan Padmanaban
Jan 16, 2016·PLoS Neglected Tropical Diseases·Joana FariaAnabela Cordeiro-da-Silva
Jan 9, 2009·Molecular Biology Reports·Esmeralda Parra-PeralboMiguel Aguilar
Dec 18, 2013·PLoS Neglected Tropical Diseases·Inês LoureiroAnabela Cordeiro-da-Silva
Feb 10, 2021·G3 : Genes - Genomes - Genetics·Shanshan ZhangJi-Long Liu
Oct 1, 1983·Journal of Bacteriology·K G MacPheeS M Schuster

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