Two Bacterial Diterpene Synthases from Allokutzneria albata Produce Bonnadiene, Phomopsene, and Allokutznerene

Angewandte Chemie
Lukas LauterbachJeroen S Dickschat

Abstract

Two diterpene synthases from Allokutzneria albata were studied for their products, resulting in the identification of the new compound bonnadiene from the first enzyme. Although phylogenetically unrelated to fungal phomopsene synthase, the second enzyme produced a mixture of phomopsene and a biosynthetically linked new compound, allokutznerene, as well as spiroviolene. Both enzymes were subjected to in-depth mechanistic studies involving isotopic labelling experiments, metal-cofactor variation, and site-directed mutagenesis. Oxidation products of phomopsene and allokutznerene are also discussed.

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Citations

Apr 30, 2019·Angewandte Chemie·Jan RinkelJeroen Sidney Dickschat
Jun 12, 2019·Angewandte Chemie·Jeroen S Dickschat
Oct 18, 2019·Chemical Communications : Chem Comm·Jan RinkelJeroen S Dickschat
Jun 6, 2019·Beilstein Journal of Organic Chemistry·Jan Rinkel, Jeroen S Dickschat
Sep 26, 2019·Chembiochem : a European Journal of Chemical Biology·Jan Rinkel, Jeroen S Dickschat
Sep 3, 2019·Chembiochem : a European Journal of Chemical Biology·Jan RinkelJeroen S Dickschat
Apr 29, 2020·Angewandte Chemie·Lukas LauterbachJeroen S Dickschat
Apr 8, 2020·Organic & Biomolecular Chemistry·Lukas Lauterbach, Jeroen S Dickschat
May 23, 2020·Chemistry : a European Journal·Houchao Xu, Jeroen S Dickschat
Dec 17, 2019·Beilstein Journal of Organic Chemistry·Eric J N HelfrichJon Clardy
Aug 28, 2020·World Journal of Microbiology & Biotechnology·Pranav Bhaskar, Dipti Sareen
Jan 30, 2019·Organic & Biomolecular Chemistry·Immo BurkhardtJeroen S Dickschat
Oct 22, 2020·Chembiochem : a European Journal of Chemical Biology·Houchao Xu, Jeroen S Dickschat
Nov 11, 2020·Natural Product Reports·Jeffrey D RudolfZining Li
Mar 27, 2021·Chemistry : a European Journal·Lukas LauterbachJeroen S Dickschat
Jul 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Rong ChenTiangang Liu
Mar 13, 2019·Organic Letters·Jan Rinkel, Jeroen S Dickschat
Jan 6, 2022·Organic Letters·Houchao XuJeroen S Dickschat

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