Two Bariatric Surgical Procedures Differentially Alter the Intestinal Microbiota in Obesity Patients.

Obesity Surgery
Guolin ChenShiqi Jia

Abstract

To explore the intestinal microbiota composition affected by the two most widely used procedures of bariatric surgery, laparoscopic sleeve gastrectomy (LSG) and laparoscopic roux-en-Y gastric bypass (LRYGB), in Chinese obesity patients. Stool samples were collected from the obese patients before (n = 87) and with follow-up after the surgery (n = 53). After DNA extraction, 16S rDNA (V3 + V4 regions) sequencing was completed on Illumina HiSeq 2500 sequencing platform. The samples were analyzed base on four groups, pre-LSG (n = 54), pre-LRYGB (n = 33), post-LSG (n = 33), and post-LRYGB (n = 20). The linear mixed models were used to analyze the alteration of intestinal microbiota before and after the surgeries of LSG or LRYGB. Student's t test and χ2 test were used for analysis of independent groups; Metastats analysis was used to compare the relative abundance of bacteria, and Pearson correlation and Spearman correlation analysis were used to test the correlation between indicated groups. 87 patients were included and 53 (60.92%) of them completed the follow-up (9.60 ± 3.92 months). Body mass index (BMI) decreased from 37.84 ± 6.16 kg/m2 to 26.22 ± 4.33 kg/m2 after LSG and from 45.75 ± 14.26 kg/m2 to 33.15 ± 10.99 kg/m2 after LRYG...Continue Reading

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Citations

May 20, 2020·Frontiers in Endocrinology·Mohammed K Hankir, Florian Seyfried
Nov 21, 2020·Journal of Pharmaceutical and Biomedical Analysis·Sergio Sanchez-CarrilloManuel Ferrer
Jul 22, 2021·Reviews in Endocrine & Metabolic Disorders·Carolina Gutiérrez-RepisoFrancisco J Tinahones
Aug 28, 2021·Nutrients·Maria CerretoFrancesca Romana Ponziani

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