Two-carrier influx of neutral amino acids into rabbit ileal mucosa

The Journal of Physiology
J Y PatersonM W Smith

Abstract

1. The influx of serine, alanine and methionine across the brush border membrane of the rabbit ileal mucosa has been measured during short periods of incubation. 2. A kinetic analysis of the uptake data, assuming one mediated entry mechanism or one mediated entry mechanism plus a diffusion component to be present, does not provide an adequate explanation for the results obtained. Methionine inhibition of serine uptake provided direct evidence that the diffusive entry of serine into the rabbit ileum was small or non-existent. 3. Data taken from amino acid inhibition and substrate-uptake experiments, fitted simultaneously to a double hyperbolic model of amino acid uptake, give good agreement between predicted and experimental results. There is also good quantitative agreement between computer-derived kinetic constants in the present work and similar constants obtained previously using a different method of analysis. 4. Present work supports the general hypothesis that neutral amino acids use two mediated pathways to enter the rabbit ileal mucosa. The possible physiological significance of these results and their probable effect on currently held concepts of how amino acids cross the brush border membrane of the rabbit intestinal ...Continue Reading

Citations

Jan 1, 1982·The Journal of Membrane Biology·B R StevensE M Wright
Jan 1, 1982·The Journal of Membrane Biology·A K MircheffE M Wright
Apr 10, 2007·The Journal of Membrane Biology·M O'MaraS Bröer
Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J Lerner, D L Larimore
Apr 1, 1983·Pflügers Archiv : European journal of physiology·G CassanoH Murer
Mar 15, 1980·Experientia·M W Smith, P S James
Jan 1, 1982·Die Nahrung·M Friedrich
Feb 16, 1983·Biochimica Et Biophysica Acta·M W Smith, J Y Paterson
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·D SaidaneG Peres
Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·M W Smith

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