Two cases of unilateral cone-rod dysfunction with negative electroretinograms

Documenta Ophthalmologica. Advances in Ophthalmology
Kenji OzawaYozo Miyake

Abstract

To report the findings in two patients with unilateral cone-rod dysfunction with the a-wave larger than the b-wave, i.e., negative-type, full-field electroretinogram (ERG). Standard ophthalmological examinations were performed including the medical history, measurements of the best-corrected visual acuity and intraocular pressures, slit-lamp biomicroscopy, ophthalmoscopy, spectral-domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, and perimetry. ERG examinations were carried out with the ISCEV standard. Immunoblot analysis using the patient's sera was performed to determine the presence of the recoverin1 antibody. The common findings in these two patients were: unilateral, male sex, sudden onset of photophobia or a reduction in the vision at an advanced age, preserved visual acuity, no complaint of night blindness, normal fundus appearance, negative-type dark-adapted 3.0 ERGs with reduced a-wave amplitudes, absent light-adapted 3.0 ERGs, and very reduced but recordable dark-adapted 0.01 ERGs. In addition, the multifocal ERGs in all areas except that in a hexagonal area within a 2.5° radius of the fovea were very reduced. Patients with similar findings have been reported earlier, but the subno...Continue Reading

References

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Citations

Jun 27, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Yoshiaki ShimadaAtsuhiro Tanikawa
Nov 13, 2020·Japanese Journal of Ophthalmology·Toshiaki HirakataYozo Miyake

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