Two cell populations participate in clearance of damaged hair cells from the sensory epithelia of the inner ear

Hearing Research
Keiko HiroseMark E Warchol

Abstract

The cochlea and the vestibular organs are populated by resident macrophages, but their role in inner ear maintenance and pathology is not entirely clear. Resident macrophages in other organs are responsible for phagocytosis of injured or infected cells, and it is likely that macrophages in the inner ear serve a similar role. Hair cell injury causes macrophages to accumulate within proximity of damaged regions of the inner ear, either by exiting the vasculature and entering the labyrinth or by the resident macrophages reorganizing themselves through local movement to the areas of injury. Direct evidence for macrophage engulfment of apoptotic hair cells has been observed in several conditions. Here, we review evidence for phagocytosis of damaged hair cells in the sensory epithelium by tissue macrophages in the published literature and in some new experiments that are presented here as original work. Several studies also suggest that macrophages are not the only phaogocytic cells in the inner ear, but that supporting cells of the sensory epithelium also play an important role in debris clearance. We describe the various ways in which the sensory epithelia of the inner ear are adapted to eliminate damaged and dying cells. A collabo...Continue Reading

Citations

Jul 31, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Debara L Tucci, Joni K Doherty
Jul 25, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Tadao OkayasuJoseph B Nadol
Dec 11, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Tadao OkayasuJoseph B Nadol
Sep 6, 2018·Cold Spring Harbor Perspectives in Medicine·Mark E Warchol
Jul 30, 2019·Frontiers in Neurology·Wei LiuHelge Rask-Andersen
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Dec 10, 2021·Frontiers in Neurology·Wei LiuHelge Rask-Andersen

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