PMID: 9421801Jan 9, 1998Paper

Two circuits to convert short-term memory into long-term memory

Medical Hypotheses
C W Wong

Abstract

According to a brain model, encoding synapses record presynaptic axonal 'on-off' patterns as memory, and modulating synapses convert short-term memory into long-term memory by helping encoding synapses develop long-term potentiation and depression. Sensory organs conduct sounds and images as series of axonal 'on-off' patterns to encoding synapses of perceptive cortices where the patterns are recorded, computed, and rerouted to mesotemporal lobes, hippocampal formations and higher cortical centers. Mesotemporal lobes and hippocampal formations compute and convey the 'on-off' patterns to dorsomedial thalamic nuclei (circuit A), septal nuclei and mammillary bodies (circuit B), where the patterns are computed and conveyed to prefrontal lobes (circuit A) and anterior thalamic nuclei (circuit B) respectively. Anterior thalamic nuclei project axonal 'on-off' patterns to cingulate gyri that compute and convey the patterns to prefrontal lobes. Finally, prefrontal lobes send modulating axons to encoding synapses of perceptive cortices. Amnesia of Korsakoff's syndrome results from unilateral dysfunction of circuit A and contralateral dysfunction of circuit B, or bilateral dysfunction of either. The fact that there is more severe memory de...Continue Reading

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Citations

Sep 29, 2004·Toxicology and Applied Pharmacology·Adrinel Vázquez, Sandra Peña de Ortiz
Dec 23, 1999·Medical Hypotheses·C W Wong

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