Two circulating neutrophil populations in acute inflammation in mice.

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Hildur H ArnardottirIngibjorg Hardardottir

Abstract

Recent studies indicate that neutrophils are heterogeneous and may have an immunosuppressive role in addition to their well-known phagocytic and bactericidal function. This study examined neutrophil subpopulations in the circulation, peritoneum, spleen and bone marrow from mice at various time points after induction of acute inflammation. MATERIAL, TREATMENT AND METHODS: Female C57BL/6 mice were injected intraperitoneally with lipopolysaccharide (LPS). Blood, peritoneal, spleen and bone marrow cells were collected and counted and expression of surface molecules and chemokine receptors analyzed with flow cytometry. Chemokine and cytokine concentrations in serum and peritoneal fluid were determined by ELISA. Neutrophil numbers in the circulation decreased following administration of LPS but reached similar numbers to those prior to inflammation at 8 h. At that time point, two distinct neutrophil populations were present in the circulation. These two neutrophil populations differed in size, granularity and expression of CD11b and Ly6G. Few neutrophils were recruited into the peritoneum until 24 h after administration of LPS at a time when the neutrophils in the...Continue Reading

References

Sep 1, 1988·Current Opinion in Immunology·A A AderemK A Barker
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A HaziotS M Goyert
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ekihiro SekiKenji Nakanishi
Apr 3, 2003·The Journal of Clinical Investigation·Graciela AndoneguiPaul Kubes
Mar 19, 2004·The Journal of Biological Chemistry·Jeremy J RoseSundararajan Venkatesan
Jan 4, 2006·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J-J LiuY-Z He
Dec 2, 2006·American Journal of Respiratory and Critical Care Medicine·Fabrício Rios-SantosFernando de Queiroz Cunha
May 27, 2008·Pediatric Clinics of North America·W Joshua Frazier, Mark W Hall
Jan 26, 2010·Biochemical and Biophysical Research Communications·Kevin R KastenCharles C Caldwell
Jun 4, 2010·Contributions to Nephrology·Steven M Opal
Jan 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erin F McAvoyPaul Kubes
Aug 17, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hicham BouabeJürgen Heesemann
Oct 21, 2011·Nature Immunology·Martin S DaveyMarco A Cassatella
Dec 14, 2011·The Journal of Clinical Investigation·Janesh PillayLeo Koenderman

❮ Previous
Next ❯

Citations

Apr 24, 2014·Advances in Wound Care·Carlos ZgheibKenneth W Liechty
Oct 1, 2014·Journal of Immunological Methods·Valgerdur TomasdottirJona Freysdottir
Nov 17, 2015·Mediators of Inflammation·Jakub Kryczka, Joanna Boncela
Oct 31, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·David D LoH Peter Lorenz
Jun 24, 2014·Seminars in Immunology·Kate WicksKimberly A Mace
Oct 1, 2016·Oncotarget·Camilla Rydberg MillrudKarin Leandersson
Jul 10, 2018·Oxidative Medicine and Cellular Longevity·Domingos M S PereiraElizabeth S Fernandes
Mar 25, 2021·Mucosal Immunology·Cecilia Johansson, Freja C M Kirsebom

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.