PMID: 7008031Dec 11, 1980Paper

Two classes of Mu lig mutants: the thermosensitives for integration and replication and the hyperproducers for ligase

Nucleic Acids Research
L PaolozziC Marchelli

Abstract

We have previously shown that Mu restores an active DNA replication at non-permissive temperature in E. coli K12 ligts7 strains. In this paper we describe two new types of phage mutants for the Mu lig function. The Mu ligts mutants are conditional lethals defective for both integration and replication of DNA, unable to 'complement' the bacterial lig mutation; the map between B and lys. The mutants of the other type, on the other hand, are able to restore to a maximum level the activity impaired by the ligts7 mutation in the host. We suggest the hypothesis that the product of Mu lig gene could be part of a complex as a topoisomerase.

References

Sep 25, 1979·Journal of Molecular Biology·E Ljungquist, A I Bukhari
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L PaolozziE Calef
May 14, 1979·Biochemical and Biophysical Research Communications·L PaolozziH Marcovich
May 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·P Modrich, I R Lehman
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R A Fitts, A L Taylor

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Citations

Jul 1, 1989·Molecular & General Genetics : MGG·L PaolozziP Ghelardini
Jan 1, 1982·Molecular & General Genetics : MGG·T GoosenP Van de Putte
Jan 11, 1982·FEBS Letters·P GhelardiniL Paolozzi
Nov 30, 1989·Biochemical and Biophysical Research Communications·C Barron, E G Bade

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