Mar 22, 2013

Two clusters of GABAergic ellipsoid body neurons modulate olfactory labile memory in Drosophila

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Zhiping ZhangAike Guo

Abstract

In Drosophila, aversive olfactory memory is believed to be stored in a prominent brain structure, the mushroom body (MB), and two pairs of MB intrinsic neurons, the dorsal paired medial (DPM) and the anterior paired lateral (APL) neurons, are found to regulate the consolidation of middle-term memory (MTM). Here we report that another prominent brain structure, the ellipsoid body (EB), is also involved in the modulation of olfactory MTM. Activating EB R2/R4m neurons does not affect the learning index, but specifically eliminates anesthesia-sensitive memory (ASM), the labile component of olfactory MTM. We further demonstrate that approximately two-thirds of these EB neurons are GABAergic and are responsible for the suppression of ASM. Using GRASP (GFP reconstitution across synaptic partners), we reveal potential synaptic connections between the EB and MB in regions covering both the presynaptic and postsynaptic sites of EB neurons, suggesting the presence of bidirectional connections between these two important brain structures. These findings suggest the existence of direct connections between the MB and EB, and provide new insights into the neural circuit basis for olfactory labile memory in Drosophila.

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Mentioned in this Paper

Avoidance Learning
Factor V
Neurons
Brain
Drosophila
Smell Perception
Odors
Ganglia, Invertebrate
Visual Suppression
Synapses

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