PMID: 12782336Jun 5, 2003Paper

Two clusters of serum midkine levels in drug-naive patients with schizophrenia

Neuroscience Letters
Eiji ShimizuMasaomi Iyo

Abstract

Midkine (MK) is a heparin-binding growth factor implicated in various biological phenomena such as development of the hippocampus and anxiety. We evaluated serum MK levels of drug-naive (n=15) and medicated (n=25) patients with schizophrenia, and age- and sex-matched normal controls (n=38). The patients showed two clusters in the levels. Four drug-naive patients (26.7%) and two medicated patients (8.0%) had abnormally high values, but no controls did, there being a significant difference in the numbers (P=0.003, Fisher's exact test). Furthermore, in other patients, the mean MK levels in drug-naive schizophrenia (0.30+/-0.10 ng/ml) were significantly (P=0.018, Fisher's protected least significant difference test) decreased than those in the controls (0.40+/-0.12 ng/ml). These suggest that there are two clusters of serum MK abnormalities in drug-naive patients with schizophrenia.

References

Jan 1, 1992·Schizophrenia Bulletin·R M MurrayS W Lewis
Jan 1, 1993·Schizophrenia Bulletin·B Bogerts
Nov 5, 1997·Neuroscience Letters·K MishimaT Kirino
Apr 28, 2000·The American Journal of Psychiatry·Z Kronfol, D G Remick
Jul 20, 2002·Journal of the Neurological Sciences·Manabu WadaKiyomitsu Oyanagi

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Citations

May 4, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ragaa H M SalamaTakashi Muramatsu
Jul 25, 2008·Proteomics·Takashi Muramatsu, Hisako Muramatsu
May 23, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Susanne LucasPablo Hernáiz Driever
Nov 23, 2017·The International Journal of Neuroscience·Erman Esnafoglu, Selma Cirrik

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