Two color flow cytometric analysis of concomitant acute myeloid leukemia and chronic lymphocytic leukemia

Cytometry
K R TamulJ D Folds

Abstract

During evaluation for macrocytic anemia and thrombocytopenia, a 74-year-old female was found to have a leukocytosis with two apparent populations of malignant cells identified in her peripheral blood smear and bone marrow aspirate. Morphologic characteristics of the two cell types were unusual, and cytochemical assays yielded ambiguous results. Two-color flow cytometric analysis demonstrated two distinct cell populations with immunophenotyping patterns consistent with chronic lymphocytic leukemia (CD5+/CD20+) and acute myelocytic leukemia (CD33+/CD34+), detected concurrently. The concomitant appearance of CLL and AML has been reported only rarely. The use of two-color flow cytometry to differentiate the populations demonstrates the utility of this technology in resolving unusual hematological malignancies.

References

Nov 1, 1979·British Journal of Haematology·E LawlorI J Temperley
Aug 1, 1977·Pediatriia·D K BondareI Ia Baravika
Aug 1, 1973·British Journal of Haematology·P D Roberts, P M Forster
Sep 26, 1970·The Medical Journal of Australia·B J O'NeillG P Tauro
Oct 1, 1980·American Journal of Clinical Pathology·M T Hull, J A Griep

❮ Previous
Next ❯

Citations

Jul 1, 1997·Leukemia Research·L S SylvesterJ S Moore
Jul 14, 2010·Southern Medical Journal·Khalil M CharafeddineZiad M Salem
Oct 26, 2012·Hematology/oncology and Stem Cell Therapy·Zachariah DeFilippEntezam Sahovic
Mar 17, 2009·Journal of Family Nursing·Nathan R Pyle
Jan 13, 2000·American Journal of Clinical Pathology·M I FielH C Bodenheimer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.