Two-compartment micellar assemblies obtained via aqueous self-organization of synthetic polymer building blocks

Langmuir : the ACS Journal of Surfaces and Colloids
Andreas F ThünemannHelmuth Möhwald

Abstract

We synthesized a symmetric linear ABCBA pentablock copolymer consisting of poly(ethylene oxide), poly(gamma-benzyl l-glutamate), and a poly(perfluoro ether) (fluorolink). The different blocks are highly immiscible with each other and form two-compartment micelles of mainly cylindrical shape in aqueous solution with lengths in the range of 100 to 200 nm and diameters of about 24 nm. The poly(perfluoro ether) (C blocks) forms the liquidlike center of the micelles (d = 6 nm). This is surrounded by a first shell of ca. 2 nm thickness consisting of beta-sheets of poly(gamma-benzyl l-glutamate) (B blocks) and a second 7 nm shell of poly(ethylene oxide) (A blocks). The A blocks provide water solubility, and the B and C blocks form separated hydrophobic compartments. This work is a contribution to the development of multicompartment micelles devoted to mimic transport proteins such as serum albumins in long-term development.

References

Sep 29, 1976·Journal of the American Chemical Society·M Rinaudo, A Domard
Oct 2, 2004·Science·Blaire Van ValkenburghJohn Damuth

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Citations

Jul 20, 2007·Chemical Communications : Chem Comm·Jin-Song HuShuit-Tong Lee
Oct 14, 2007·Physical Chemistry Chemical Physics : PCCP·Jun XiaChongli Zhong
Oct 8, 2009·Chemical Communications : Chem Comm·Jean-François GohyUlrich S Schubert
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Jul 19, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Weixin KongBaohui Li
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Oct 18, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Zhibo LiTimothy P Lodge

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