Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.

Cell
Philip J M BrouwerRogier W Sanders

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic.

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Citations

Mar 17, 2021·Wiener klinische Wochenschrift·Franz X Heinz, Karin Stiasny
Apr 20, 2021·Nature·Prabhu S ArunachalamBali Pulendran
Jun 24, 2021·FEMS Microbiology Reviews·Milankumar PatelHoward E Gendelman
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Aug 29, 2021·Vaccines·Laure AlbrechtCaroline Passaes
Sep 3, 2021·The Medical Journal of Australia·Leah GroutNick Wilson

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Methods Mentioned

BETA
size exclusion chromatography
electron microscopy
glycosylation
ELISA
enzyme-linked immunosorbent assay
flow cytometry
bronchoalveolar lavage
FACS
transfection
affinity purification

Clinical Trials Mentioned

NCT03816137
NCT03961438
NCT04046978

Software Mentioned

nsEM
Nanoplot
house
[UNK]
GraphPad
INTELLISPACE PORTAL
Excel
GraphPad Prism
XCalibur
Guppy

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