Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.

Philip J M BrouwerRogier W Sanders


The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic.


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Methods Mentioned

size exclusion chromatography
electron microscopy
enzyme-linked immunosorbent assay
flow cytometry
bronchoalveolar lavage
affinity purification

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Software Mentioned

GraphPad Prism

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