Two-component systems in Streptomyces: key regulators of antibiotic complex pathways

Microbial Cell Factories
Héctor RodríguezRamón I Santamaría

Abstract

Streptomyces, the main antibiotic-producing bacteria, responds to changing environmental conditions through a complex sensing mechanism and two-component systems (TCSs) play a crucial role in this extraordinary "sensing" device.Moreover, TCSs are involved in the biosynthetic control of a wide range of secondary metabolites, among them commercial antibiotics. Increased knowledge about TCSs can be a powerful asset in the manipulation of bacteria through genetic engineering with a view to obtaining higher efficiencies in secondary metabolite production. In this review we summarise the available information about Streptomyces TCSs, focusing specifically on their connections to antibiotic production.

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Methods Mentioned

BETA
electrophoretic mobility shift
footprinting
inmunoprecipitation
ChIP-chip

Software Mentioned

II
PFAM
TopPred

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