Two components of delayed rectifier current in canine atrium and ventricle. Does IKs play a role in the reverse rate dependence of class III agents?

Circulation Research
G A Gintant

Abstract

Because the number and characteristics of delayed rectifier K+ current (IK) components vary between species, the role of each component in the action potential and modulation by class III agents is uncertain. To address these issues, IK was assessed in adult isolated canine ventricular and and atrial myocytes by using whole-cell and perforated-patch techniques. IK components were characterized by using two complementary approaches: a kinetic approach (based on biexponential fits to deactivating tail currents) and a pharmacological approach approach (using the methanesulfonanilide compound E-4031). In ventricular myocytes, two exponential tail current components were distinguished; these components differed in the voltage and time dependence of activation and the effect of lower (K+). Both kinetic components contributed equally to peak tail current amplitude (measured at -35 mV) after a single 300-ms pulse to 5 mV, simulating an action potential. By use of E-4031, rapidly and slowly activating components described kinetically were identified. The activation kinetics and rectification properties of canine IKr and IKs are qualitatively similar to those described previously for guinea pigs. In contrast, canine IKr and IKs deactivat...Continue Reading

References

Aug 1, 1988·The Journal of General Physiology·R Horn, A Marty
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Mar 24, 1993·JAMA : the Journal of the American Medical Association·R L WoosleyR A Gillis

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Citations

Dec 2, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Gábor HarmatiPéter P Nánási
Apr 6, 2006·Pflügers Archiv : European journal of physiology·Balázs HorváthTamás Bányász
Jun 24, 2011·Pflügers Archiv : European journal of physiology·Iván A Aréchiga-FigueroaJosé A Sánchez-Chapula
Nov 11, 1998·The American Journal of Cardiology·A O Grant
Aug 10, 1999·European Journal of Pharmacology·Y XueK Hashimoto
Mar 8, 2003·Journal of Molecular and Cellular Cardiology·Martin Tristani-Firouzi, Michael C Sanguinetti
Oct 7, 2000·Clinical and Experimental Pharmacology & Physiology·H J Witchel, J C Hancox
Feb 1, 1997·Pacing and Clinical Electrophysiology : PACE·A O Grant
Mar 1, 2000·Journal of Cardiovascular Electrophysiology·R B RobinsonM R Rosen
May 10, 2001·Journal of Molecular and Cellular Cardiology·G N Tseng
Sep 5, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Arun SridharCynthia A Carnes
May 18, 2012·TheScientificWorldJournal·Eleftherios M KallergisPanos E Vardas
Oct 3, 2003·Journal of Cardiovascular Electrophysiology·Paulus KirchhofWilhelm Haverkamp
Apr 16, 1998·The American Journal of Cardiology·R KaramA Moore
Dec 20, 2002·Journal of Cardiovascular Pharmacology and Therapeutics·Paul DorianDavid Newman
Dec 13, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Hanne Borger RasmussenNanna Koschmieder Jørgensen
Oct 10, 1998·Japanese Circulation Journal
Dec 13, 2005·Journal of Internal Medicine·D M Roden
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matti VornanenAntti Nurmi
Mar 10, 2000·Journal of Cardiovascular Pharmacology·H MarschangW Schöls
Oct 17, 2001·Journal of Cardiovascular Pharmacology·T YangD M Roden
Aug 13, 1998·Journal of Cardiovascular Pharmacology·Y XueK Hashimoto
Jun 27, 2003·Journal of Cardiovascular Pharmacology·Gary L StumpJoseph J Lynch
Dec 22, 1999·Journal of Cardiovascular Pharmacology·X Q QiP Dorian
May 7, 2011·British Journal of Pharmacology·András Varró, István Baczkó

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