Two controls of cell proliferation underlie cancer relapse

Journal of Cellular Physiology
Arthur B Pardee, Chiang J Li

Abstract

Much progress has been made in understanding the basis of cancer. Current therapies can effectively shrink tumors. But they frequently relapse, metastasize to other locations, and are lethal. Effective therapies are very much needed for preventing this relapse. Creation of a eukaryotic organism commences with one original stem cell, a fertilized egg, which multiplies and differentiates. Mutations of normal stem cells can produce cancer stem cells (CSC). These cells may resist chemotherapy, proliferate, and produce new tumors. Human chorionic gonadotrophin (hCG) is composed of two proteins (alpha and beta) that bind to the cell membrane and activate a number of intracellular pathways. hCG has been shown to activate the proliferation of cancer stem cells. Cyclin dependent regulation of the adult cells is created in normal differentiation and replaces the hCG regulation of stem cells. To selectively kill the cancer stem cells conventional cancer therapies could be followed with a therapy based on inactivating human chronic gonadotrophin (HCG). For example chemically modified prostaglandins like RU486 prevent binding of the unmodified steroid to hCG and inactivate hCG.

References

Jul 27, 2010·Molecular and Cellular Endocrinology·R K IlesS A Butler
Sep 29, 2011·Molecular and Cellular Endocrinology·Sunshine Daddario Axlund, Carol A Sartorius
Feb 22, 2012·Endocrine-related Cancer·Claudia LanariAlfredo A Molinolo
Mar 30, 2012·Reproductive Biology and Endocrinology : RB&E·Laurence A Cole
Apr 17, 2014·Breast Cancer Management·Julia Santucci-PereiraJose Russo
Jan 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Youzhi LiChiang J Li
Apr 9, 2015·Nature Reviews. Clinical Oncology·Naoko TakebeS Percy Ivy
Sep 20, 2017·Molecular and Cellular Biology·Sayyed K ZaidiGary S Stein

❮ Previous
Next ❯

Citations

Sep 4, 2021·Frontiers in Oncology·Dan XieTing Ye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Related Papers

Journal of Reproduction and Fertility. Supplement
I BoimeD Chaplin
The Medical Journal of Australia
P Bradley
The Medical Journal of Australia
H Perelberg
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
D BelletC Bohuon
© 2022 Meta ULC. All rights reserved