Two cycles of plasma rich in growth factors (PRGF-Endoret) intra-articular injections improve stiffness and activities of daily living but not pain compared to one cycle on patients with symptomatic knee osteoarthritis

Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA
Víctor VaquerizoEduardo Anitua

Abstract

To assess the clinical efficacy and safety of a treatment based on one cycle versus two cycles of intra-articular injections of plasma rich in growth factors (PRGF-Endoret) on patients with knee osteoarthritis (OA). Ninety patients with knee OA were included and evaluated. A total of 48 patients received one cycle (OC group) (3 injections on a weekly basis), while 42 patients received two cycles of PRGF-Endoret (TC group) spaced 6 months between them. Patients were evaluated with LEQUESNE and WOMAC scores before treatment and after 48 weeks. Safety assessment was also performed. A significant reduction of all assessed outcome measures was shown for both groups at 48 weeks compared with baseline values (P < 0.001). Patients of TCs group showed a significantly higher reduction (P < 0.05) in WOMAC stiffness subscales. Regarding LEQUESNE INDEX, a significantly higher reduction was observed in the TC group in all subscales except in pain score. In the maximum walking distance subscale (MCD), the improvement rate was 31.8% higher for the TCs group compared with the OC group (P < 0.01). In addition, the TC group showed a significant improvement in LEQUESNE activities of daily living (ADV) and global subscales of 14.7 and 11.8% (P < 0....Continue Reading

References

Jan 1, 1987·Scandinavian Journal of Rheumatology. Supplement·M G LequesneP Gerard
Feb 24, 2006·The New England Journal of Medicine·David T Felson
Sep 16, 2006·Annals of the Rheumatic Diseases·K D BrandtL van de Putte
Jun 15, 2007·Arthritis Research & Therapy·Andy Dray, Simon J Read
Feb 24, 2009·Arthritis Research & Therapy·David T Felson
Jun 23, 2010·Journal of Cellular Physiology·Paola BendinelliMaria Alfonsina Desiderio
Aug 18, 2010·Archives of Orthopaedic and Trauma Surgery·Ana Wang-SaegusaMontserrat Garcia-Balletbó
Sep 10, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Daniel J LeongHui B Sun
Dec 2, 2010·Nature Reviews. Rheumatology·Mohit KapoorHassan Fahmi
Aug 23, 2011·The American Journal of Sports Medicine·Gerben M van BuulGerjo J V M van Osch
Oct 4, 2011·Biochemical Pharmacology·Santos CastañedaGabriel Herrero-Beaumont
Nov 1, 2011·Bone·Johanne Martel-PelletierJean-Pierre Pelletier
Dec 29, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Giuseppe FilardoMaurilio Marcacci
Mar 6, 2012·Bone·Carla R Scanzello, Steven R Goldring
Jul 31, 2012·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Mikel SánchezEduardo Anitua
Mar 19, 2013·Annals of the Rheumatic Diseases·Juan Fernández-TajesFrancisco J Blanco
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kimberly A WallerGregory D Jay
Apr 13, 2013·Tissue Engineering. Part a·Fiorella DescalziVincenzo Di Marzo
May 22, 2013·Nature Reviews. Rheumatology·Christopher B Little, David J Hunter
Sep 21, 2013·Nature Reviews. Rheumatology·Anne-Marie Malfait, Thomas J Schnitzer
Oct 1, 2013·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Víctor VaquerizoEduardo Anitua
Nov 28, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·G FilardoM Marcacci
Apr 2, 2014·Nature Reviews. Rheumatology·Matthew ThakurRalf Baron
Apr 22, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Alberto GobbiGeorgios Karnatzikos
Sep 4, 2014·Current Rheumatology Reports·Johannah Sanchez-AdamsFarshid Guilak
Nov 25, 2014·British Journal of Sports Medicine·Augustinus B M LaudyMaarten H Moen
Mar 31, 2015·The American Journal of Sports Medicine·Ryosuke SakataA Hari Reddi
Aug 4, 2015·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Gökay GörmeliKadir Ertem
Oct 4, 2015·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Carlos J MeheuxJoshua D Harris

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Citations

Feb 23, 2020·International Journal of Molecular Sciences·Erminia Mariani, Lia Pulsatelli

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