Two cytochrome P450 aromatase genes in the hermaphrodite ricefield eel Monopterus albus: mRNA expression during ovarian development and sex change

The Journal of Endocrinology
Yang ZhangLihong Zhang

Abstract

Previously, the ricefield eel (Monopterus albus) was speculated to have only one cytochrome p450 aromatase gene. In this study, however, the cDNAs encoding two distinct cytochrome p450 aromatases, cyp19a1a and cyp19a1b, were isolated. The genomic organizations of both cyp19 genes were conserved when compared with other teleosts. Northern blot detected an abundant expression of cyp19a1a in the ovary, and cyp19a1b in the hypothalamus. RT-PCR coupled with Southern blot showed that cyp19a1a was expressed predominantly in the gonads of both sexes, with higher levels in the ovary than testis, while cyp19a1b was expressed in all the tissues examined in the male, but only in the brain and pituitary in the female. The levels of cyp19a1a mRNA in the ovary were increased significantly during vitellogenesis, but decreased significantly at mature stage. The levels of cyp19a1b mRNA in the brain and pituitary did not vary significantly during vitellogenesis. As ovarian development shifted from vitellogenesis to maturation, the levels of cyp19a1b mRNA was decreased significantly in the brain, but increased significantly in the pituitary. During natural sex change from female to male, the levels of cyp19a1a mRNA in the gonad were significantly ...Continue Reading

Citations

Feb 2, 2010·Frontiers in Neuroendocrinology·Nicolas DiotelOlivier Kah
May 27, 2014·General and Comparative Endocrinology·Yang ZhangWeimin Zhang
Dec 6, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Timothy S BretonDavid L Berlinsky
Aug 21, 2016·Molecular Reproduction and Development·Hui LiuNeil J Gemmell
Mar 14, 2019·Frontiers in Genetics·Chih-Hsiang Yang, John Andrew Pospisilik
Jun 6, 2018·Frontiers in Endocrinology·Zulvikar Syambani Ulhaq, Mitsuyo Kishida
Jun 26, 2020·General and Comparative Endocrinology·Rose M H DriscollSuzy C P Renn
Nov 13, 2020·Physiological Reviews·Yoshitaka NagahamaMasaru Nakamura

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