Two-day quadruple therapy for cure of Helicobacter pylori infection: a comparative, randomized trial

The American Journal of Gastroenterology
Xavier CalvetM Navarro

Abstract

We sought to compare a 2-day quadruple therapy with a 14-day triple therapy in the treatment of Helicobacter pylori infection. Eighty-one consecutive patients with an endoscopically diagnosed peptic ulcer and demonstrated infection by H. pylori were included in the study. Patients were randomized to receive omeprazole 40 mg b.i.d., amoxicillin 2.5 g once daily, metronidazole 500 mg t.i.d., and bismuth subcitrate 360 mg t.i.d. for 2 days, followed by omeprazole 20 mg once daily for 6 additional days (Group 1) or a 14-day course of omeprazole 20 mg b.i.d., amoxicillin 1 g t.i.d., and metronidazole 500 mg t.i.d. (Group 2). Eradication was evaluated by antral biopsy and rapid urease test at 2 months after therapy and by C13-urea breath test after a year. Two patients were lost to follow-up at 2 months. Intention-to-treat analysis showed that H. pylori infection was cured in 29 of 42 patients (69%; 95% CI: 53-82%) in Group 1 versus 36 of 39 (92%; 95% CI: 78-98%) of patients in Group 2 (p = 0.009). Per-protocol analysis showed a cure rate of 71% (95% CI: 55-84%) (29/41 patients) and 95% (95% CI: 81-99%) (36/38 patients), respectively (p = 0.007). Fifty-five of 65 cured patients returned 1 year after treatment (26 in Group 1, 29 in Gr...Continue Reading

References

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Citations

Feb 19, 2002·Alimentary Pharmacology & Therapeutics·A Qasim, C A O'Morain
Jun 14, 2013·The Cochrane Database of Systematic Reviews·Ignacio NeumannGrigorios I Leontiadis
May 4, 2017·Helicobacter·Javier P Gisbert, Adrian G McNicholl
Oct 31, 2006·World Journal of Gastroenterology : WJG·Mohammad Hassan EmamiAbbas Esmaeili
Sep 30, 2000·Alimentary Pharmacology & Therapeutics·F CatalanoA Brogna
Jul 1, 2004·Alimentary Pharmacology & Therapeutics·N VakilJ Barth

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