Two-decade trends in primary Helicobacter pylori resistance to antibiotics in Bulgaria

Diagnostic Microbiology and Infectious Disease
Lyudmila BoyanovaIvan Mitov

Abstract

Evaluating long-term trends in antibiotic resistance can predict earlier the short-term changes in resistance patterns. The aim of the present study was to compare primary resistance rates in 501 Helicobacter pylori strains in 2007 to 2009 to those in 1990 to 1995 (179 strains) and the antibiotic MICs to detect the 20-year resistance evolution. In 2007 to 2009, strains from children exhibited lower resistance rates to metronidazole (16.4%) and ciprofloxacin (2.7%) than those from adults (27.3% and 10.3%, respectively). In 2008 to 2009, more children (29.3%) harbored clarithromycin-resistant strains compared to the adults (17.4%). Overall clarithromycin resistance rate (19.4%) in 2007 to 2009 was much higher than that in 1990 to 1995 (6.2%). MIC(90) of erythromycin in 1990 to 1995 was 142.2-fold lower than that of clarithromycin in 2007 to 2009. Clarithromycin MIC(90) increased >42-fold since 2001 to 2004. Quinolone resistance rate increased 7.7-fold, being 9.2% in 2007 to 2009 versus 1.2% in 1990 to 1995, with a 5-fold increase in MIC(90). Conversely, the amoxicillin resistance decreased from 3.2% in 1996 to 1999 to 0.4% in 2007 to 2009. The MIC(90)'s of tetracycline remained stable but MIC(50)'s of both metronidazole and tetra...Continue Reading

References

Oct 6, 2000·The Journal of Antimicrobial Chemotherapy·T AlarcónM López-Brea
Mar 23, 2002·The Journal of Antimicrobial Chemotherapy·Cliodna McNultyUNKNOWN PHLS Helicobacter Working Group
May 11, 2002·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·B GrignonJ L Fauchère
Oct 3, 2002·Journal of Medical Microbiology·Lyudmila BoyanovaZacharii Krastev
Oct 22, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S Toracchio, L Marzio
Jun 1, 2006·The Journal of Antimicrobial Chemotherapy·Matus FerechUNKNOWN ESAC Project Group
Aug 31, 2006·Journal of Clinical Gastroenterology·Nayoung KimIn Sung Song
Oct 18, 2006·Antimicrobial Agents and Chemotherapy·Erik GlockerManfred Kist
Mar 3, 2007·The Journal of Antimicrobial Chemotherapy·Vincenzo De FrancescoEnzo Ierardi
Apr 13, 2007·Clinical Microbiology Reviews·Francis Mégraud, Philippe Lehours
Oct 19, 2007·Journal of Clinical Microbiology·Intetsu KobayashiToshio Fujioka
Dec 7, 2007·Quality & Safety in Health Care·Samuel CoenenUNKNOWN ESAC Project Group
Nov 4, 2008·Emerging Infectious Diseases·Nienke van de Sande-BruinsmaUNKNOWN European Surveillance of Antimicrobial Consumption Project Group
Mar 25, 2009·Journal of Clinical Biochemistry and Nutrition·Toshihiro NishizawaToshifumi Hibi
Dec 18, 2009·Expert Review of Anti-infective Therapy·Lyudmila Boyanova, Ivan Mitov

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Citations

May 9, 2014·Diagnostic Microbiology and Infectious Disease·Lyudmila BoyanovaIvan Mitov
Mar 21, 2012·European Journal of Pediatrics·Iva HojsakSanja Kolaček
Oct 20, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Limas KupcinskasLeif P Andersen
Sep 16, 2011·Helicobacter·Josef Sýkora, Marion Rowland
Sep 23, 2014·Archives of Medical Research·Fredrick Matongo, Uchechukwu U Nwodo
Oct 11, 2014·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Leila ShokrzadehMohammad Reza Zali
May 28, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Nimet BaltasSevgi Kolayli
Apr 26, 2017·Infectious Diseases·Anna Ingibjorg GunnarsdottirEinar Stefan Bjornsson
Dec 24, 2015·Alimentary Pharmacology & Therapeutics·I ThungM A Valasek

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