Two different forms of arousal in Drosophila are oppositely regulated by the dopamine D1 receptor ortholog DopR via distinct neural circuits.

Neuron
Tim LebestkyDavid J Anderson

Abstract

Arousal is fundamental to many behaviors, but whether it is unitary or whether there are different types of behavior-specific arousal has not been clear. In Drosophila, dopamine promotes sleep-wake arousal. However, there is conflicting evidence regarding its influence on environmentally stimulated arousal. Here we show that loss-of-function mutations in the D1 dopamine receptor DopR enhance repetitive startle-induced arousal while decreasing sleep-wake arousal (i.e., increasing sleep). These two types of arousal are also inversely influenced by cocaine, whose effects in each case are opposite to, and abrogated by, the DopR mutation. Selective restoration of DopR function in the central complex rescues the enhanced stimulated arousal but not the increased sleep phenotype of DopR mutants. These data provide evidence for at least two different forms of arousal, which are independently regulated by dopamine in opposite directions, via distinct neural circuits.

References

Jun 1, 1991·The Australian and New Zealand Journal of Psychiatry·F Levy
Jun 1, 1969·Comparative Biochemistry and Physiology·G TunnicliffK Connolly
Oct 29, 1982·Science·E R Kandel, J H Schwartz
May 6, 1996·Biochemical and Biophysical Research Communications·F Gotzes, A Baumann
Mar 21, 1997·Biological Psychology·T W Robbins
Jul 21, 1998·Annals of the New York Academy of Sciences·T W RobbinsB J Everitt
Jul 31, 1998·Trends in Neurosciences·L Cahill, J L McGaugh
Mar 17, 1999·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·J R MartinM Heisenberg
Apr 10, 1999·Journal of Neurogenetics·W S Neckameyer
Nov 26, 1999·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·J R MartinM Heisenberg
Mar 8, 2000·Current Biology : CB·R J BaintonU Heberlein
Mar 10, 2000·Science·P J ShawG Tononi
May 2, 2001·Nature Reviews. Neuroscience·A J CalderA W Young
Jan 22, 2002·Trends in Neurosciences·Donald PfaffMaria Morgan
Feb 28, 2002·Behavioural Brain Research·Mary V Solanto
Oct 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mark G HearnAlan S Kopin
Nov 26, 2002·Current Biology : CB·Douglas A NitzRalph J Greenspan
Dec 20, 2002·Current Opinion in Neurobiology·Roland Strauss
Jan 3, 2003·Archives of Women's Mental Health·J FrohlichD Pfaff
Apr 25, 2003·Gene Expression Patterns : GEP·Young-Cho KimKyung-An Han
Jul 31, 2003·The European Journal of Neuroscience·Guoping FengLinda M Hall
Jul 1, 1955·Psychological Review·D O HEBB
Oct 15, 2003·Behavioural Processes·Bruno van Swinderen, Rozi Andretic
Dec 6, 2003·Science·Sean E McGuireRonald L Davis
Feb 26, 2004·Nature Genetics·Stephen T ThibaultJonathan Margolis
Feb 26, 2004·Nature Genetics·Spyros Artavanis-Tsakonas
May 14, 2004·Genes, Brain, and Behavior·W ChoF W Wolf
Feb 9, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Aaron J BobbJudith L Rapoport
Jul 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deepak P SrivastavaPeter D Evans
Jul 12, 2005·Current Biology : CB·Serge Birman
Jul 12, 2005·Current Biology : CB·Rozi AndreticRalph J Greenspan
Aug 12, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kazuhiko KumeF Rob Jackson
Oct 29, 2005·The Journal of Comparative Neurology·Donald PfaffLee-Ming Kow
Nov 8, 2005·Current Biology : CB·Thomas RiemenspergerAndré Fiala
Jun 14, 2006·Physiology & Behavior·Nino DevidzeDonald W Pfaff

❮ Previous
Next ❯

Citations

Mar 17, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Divya SitaramanTroy Zars
Mar 30, 2013·Invertebrate Neuroscience : in·Takayuki WatanabeHitoshi Aonuma
Feb 2, 2013·Behavior Genetics·Alfredo GhezziNigel S Atkinson
Oct 16, 2012·Nature Neuroscience·Taro UenoKazuhiko Kume
Apr 28, 2012·Nature Protocols·Giorgio F Gilestro
Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Laura J J NicolaïBassem A Hassan
Dec 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Thomas RiemenspergerSerge Birman
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Olga V AlekseyenkoEdward A Kravitz
Jan 7, 2011·Proceedings. Biological Sciences·Bruno Van Swinderen, Rozi Andretic
Jun 17, 2010·Genes & Development·Amanda Crocker, Amita Sehgal
Mar 19, 2011·Pharmacological Reviews·Udai Bhan Pandey, Charles D Nichols
Apr 13, 2013·Science·Nicholas J Strausfeld, Frank Hirth
Apr 3, 2014·PLoS Biology·Athanasios MetaxakisLinda Partridge
Aug 14, 2010·PloS One·James H CattersonPaul S Hartley
May 10, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aleksandra H Nall, Amita Sehgal
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tohei YokogawaHarold A Burgess
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Seth M Tomchik
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wanhe LiJosh Dubnau
Oct 29, 2013·Annual Review of Entomology·Keram Pfeiffer, Uwe Homberg
Feb 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Joseph E LeDoux
Aug 28, 2014·Human Molecular Genetics·Marlène CassarSerge Birman
Aug 28, 2012·Brain, Behavior and Evolution·Erik R DubouéAlex C Keene
Nov 21, 2014·Critical Reviews in Biochemistry and Molecular Biology·Michael KunstMichael N Nitabach
Apr 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Daniel BusheyChiara Cirelli
Mar 26, 2016·Biomedical Journal·Dan Landayan, Fred W Wolf
Dec 21, 2010·Neuroscience and Biobehavioral Reviews·Gunnar Newquist
Feb 11, 2015·Insect Biochemistry and Molecular Biology·Dyan MacWilliamMichael E Adams
Aug 13, 2010·Trends in Neurosciences·Scott Waddell
Dec 23, 2011·Developmental Neurobiology·Chien-Kuo ChenCheng-Ting Chien
Jul 7, 2011·Glia·F Rob Jackson
Jul 15, 2015·Experimental Neurology·Nathan C Donelson, Subhabrata Sanyal
Jan 6, 2015·Archives of Insect Biochemistry and Physiology·Tomáš KrůčekKlára Szakosová
Sep 23, 2014·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Maria E YurgelAlex C Keene

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

BRAIN Initiative Cell Census Network (BICCN)

The BRAIN Initiative Cell Census Network aims to identify and provide experimental access to the different brain cell types to determine their roles in health and disease. Discover the latest research from researchers in the BRAIN Initiative Cell Census Network here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Rozi AndreticRalph J Greenspan
Current Biology : CB
Rozi AndreticRalph J Greenspan
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Kazuhiko KumeF Rob Jackson
Proceedings of the National Academy of Sciences of the United States of America
Thomas RiemenspergerSerge Birman
© 2022 Meta ULC. All rights reserved