Abstract
Androgens may regulate the male skeleton either directly via activation of the androgen receptor (AR) or indirectly via aromatization of androgens into estrogen and, thereafter, via activation of estrogen receptors (ERs). There are two known estrogen receptors, ER-alpha and ER-beta. The aim of this study was to investigate the relative roles of ER-alpha, ER-beta, and AR in the maintenance of trabecular bone in male mice. Seven-month-old male mice, lacking ER-alpha (ERKO), ER-beta (BERKO), or both receptors (DERKO), were orchidectomized (orx) and treated for 3 weeks with 0.7 microg/mouse per day of 17beta-estradiol or vehicle. No reduction in trabecular bone mineral density (BMD) was seen in ERKO, BERKO, or DERKO mice before orx, showing that neither ER-a nor ER-beta is required for the maintenance of a normal trabecular BMD in male mice. After orx, there was a pronounced decrease in trabecular BMD, similar for all groups, resulting in equal levels of trabecular BMD in all genotypes. This reduction was reversed completely in wild-type (WT) and BERKO mice treated with estrogen, and no significant effect of estrogen was found in ERKO or DERKO mice. In summary, the trabecular bone is preserved both by a testicular factor, presumabl...Continue Reading
References
May 1, 1992·Endocrinology·D VanderschuerenR Bouillon
Apr 11, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G K WakleyR T Turner
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Nov 1, 1994·The Journal of Clinical Endocrinology and Metabolism·L D NonoshitaL C Giudice
Sep 1, 1994·Calcified Tissue International·D VanderschuerenR Bouillon
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D B LubahnO Smithies
Dec 1, 1995·The Journal of Clinical Endocrinology and Metabolism·A MorishimaK Qin
Sep 1, 1996·Calcified Tissue International·D VanderschuerenR Bouillon
Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J HalleenH K Väänänen
Jun 1, 1997·Endocrinology·D VanderschuerenR Bouillon
Jul 10, 1997·The New England Journal of Medicine·C CaraniE R Simpson
Oct 6, 1997·The Journal of Clinical Investigation·C W SlemendaC C Johnston
Aug 13, 1998·Bone·T JämsäJ Tuukkanen
Aug 27, 1998·The New England Journal of Medicine·J P BilezikianM M Grumbach
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·J H KregeO Smithies
Feb 19, 1999·Calcified Tissue International·P GillbergS Ljunghall
Apr 21, 1999·Clinical Endocrinology·B OngphiphadhanakulL Chailurkit
Jun 16, 1999·Endocrine Reviews·J F Couse, K S Korach
Oct 8, 1999·The Journal of Clinical Investigation·S H WindahlC Ohlsson
Apr 6, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·O K OzE R Simpson
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·O VidalC Ohlsson
Jul 14, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M HalleenH K Väänänen
Oct 18, 2000·Bone·A K SrivastavaD J Baylink
Nov 4, 2000·Bone·D VanderschuerenR Bouillon
Feb 13, 2001·Biochemical and Biophysical Research Communications·C MiyauraA Ito
Mar 21, 2001·Cell·S KousteniS C Manolagas
Apr 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A J JanckilaL T Yam
Jul 5, 2001·Biochemical and Biophysical Research Communications·L VandenputD Vanderschueren
Citations
Mar 5, 2005·European Journal of Endocrinology·Vilhelmiina ParikkaPirkko Härkönen
Mar 24, 2009·European Journal of Endocrinology·Claes Ohlsson, Liesbeth Vandenput
Oct 24, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sofia MovérareClaes Ohlsson
Feb 18, 2009·World Journal of Urology·E K StuermerK M Stuermer
Dec 10, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Marie K LindbergClaes Ohlsson
Mar 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John P Bilezikian
Apr 28, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Benjamin Z Leder, Joel S Finkelstein
Jun 22, 2011·Arthritis Research & Therapy·Ulrika IslanderHans Carlsten
Aug 21, 2002·Trends in Endocrinology and Metabolism : TEM·Sara H WindahlJan-Ake Gustafsson
Feb 5, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Zhongbo LiuShoshana Yakar
Sep 24, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Su Mi WooJi Yeon Jung
Dec 14, 2005·Bone·Anna EnjuanesAdolfo Díez-Pérez
Apr 18, 2003·Endocrinology and Metabolism Clinics of North America·Sundeep Khosla, John P Bilezikian
Mar 27, 2007·Bone·T HertrampfP Diel
Mar 24, 2004·Calcified Tissue International·T F TözümL K McCauley
Dec 12, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anna E BörjessonClaes Ohlsson
Oct 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Asa TivestenClaes Ohlsson
Aug 18, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Liesbeth VandenputDirk Vanderschueren
Apr 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Katrien VenkenDirk Vanderschueren
Sep 10, 2014·Endocrine Reviews·Dirk VanderschuerenClaes Ohlsson
Sep 11, 2008·American Journal of Physiology. Endocrinology and Metabolism·Joshua F YarrowStephen E Borst
Dec 18, 2008·American Journal of Physiology. Endocrinology and Metabolism·S H WindahlC Ohlsson
May 6, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E S Orwoll
Jan 1, 2012·BoneKEy Reports·Claes OhlssonLiesbeth Vandenput
Nov 6, 2018·Journal of Bone and Mineral Metabolism·Forough SakiGholam Hossein Ranjbar Omrani
Dec 4, 2003·Molecular Pharmacology·Sofia MovérareClaes Ohlsson
Sep 24, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Filip CallewaertDirk Vanderschueren
Feb 27, 2003·Immunology·M C ErlandssonH Carlsten
Apr 17, 2003·Endocrinology·Kathleen E McDougallJonathan H Tobias
Jun 8, 2004·Endocrine Reviews·Dirk VanderschuerenClaes Ohlsson
Jan 7, 2017·Journal of Molecular Endocrinology·H H FarmanM K Lagerquist
Jul 14, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M C ErlandssonH Carlsten
Nov 17, 2019·Cells·Jia-Feng ChenHong-Yo Kang
Jan 9, 2021·BMC Oral Health·Young-Bum SonGyu-Jin Rho
Jan 30, 2021·Trends in Endocrinology and Metabolism : TEM·Anna Maria FormentiAndrea Giustina
May 27, 2005·Maturitas·D Seidlová-WuttkeW Wuttke
Aug 6, 2010·Molecular and Cellular Endocrinology·Ulrika IslanderHans Carlsten