Two different sides of 'chemobrain': determinants and nondeterminants of self-perceived cognitive dysfunction in a prospective, randomized, multicenter study

Psycho-oncology
Kerstin HermelinkKarin Münzel

Abstract

Complaints of cognitive dysfunction are frequent among cancer patients. Many studies have identified neuropsychological compromise associated with cancer and cancer therapy; however, the neuropsychological compromise was not related to self-reported cognitive dysfunction. In this prospective study, the authors examined if confounding factors masked an underlying association of self-perceived cognitive function with actual cognitive performance. Determinants of self-perceived cognitive dysfunction were investigated. Self-perceived cognitive function and cognitive performance were assessed before treatment, at the end of treatment, and 1 year after baseline in 101 breast cancer patients randomized to standard versus intensified chemotherapy. Linear mixed-effects models were applied to test the relationships of performance on neuropsychological tests, patient characteristics, and treatment variables to self-reported cognitive function. Change of cognitive performance was tested as a predictor of change in self-reports. Self-perceived cognitive function deteriorated during chemotherapy and had partially recovered 1 year after diagnosis. The personality trait negative affectivity, current depression, and chemotherapy regimen were co...Continue Reading

References

Jun 1, 1988·Journal of Personality and Social Psychology·D WatsonA Tellegen
Jun 1, 1987·Journal of Personality·P T Costa, R R McCrae
Mar 1, 1982·Psychophysiology·J W PennebakerJ A Skelton
Jan 1, 1995·Social Psychiatry and Psychiatric Epidemiology·O E el-Rufaie, G H Absood
Mar 14, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F Perri
Jan 12, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tim A AhlesPeter M Silberfarb
Dec 23, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M PoppelreuterH H Bartsch
Mar 4, 2005·Journal of Clinical and Experimental Neuropsychology·Steven A CastellonGail A Greendale
May 3, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Helena HarderMartin J van den Bent
Jul 18, 2006·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Val Shilling, Valerie Jenkins
Aug 4, 2007·Breast Cancer Research and Treatment·Tim A AhlesPeter A Kaufman
Aug 11, 2007·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Pablo A MoraFrancisco Ceric

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Citations

Nov 12, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Christine D CraigDana M Chase
Sep 9, 2011·Breast Cancer Research and Treatment·Mei-Ling ChenShin-Cheh Chen
Nov 10, 2011·Current Psychiatry Reports·Samantha B Artherholt, Jesse R Fann
Jan 29, 2013·Journal of the International Neuropsychological Society : JINS·Robyn A HowarthHeather M Conklin
Nov 5, 2013·Seminars in Oncology Nursing·Kelly N HolohanAndrew J Saykin
Nov 19, 2013·Archives of Psychiatric Nursing·Sara MonteiroAnabela Pereira
Sep 26, 2013·International Journal of Radiation Oncology, Biology, Physics·Ansa Maer ColeDiana Steinmann
Apr 3, 2014·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Megan KenyonAnna Kate Owens
Jul 7, 2011·Clinical Genitourinary Cancer·Tone SkaaliAlv A Dahl
Nov 23, 2010·Lancet Neurology·Mustafa Khasraw, Jerome B Posner
Aug 24, 2010·Progress in Cardiovascular Diseases·Joann Lindenfeld, Patricia A Kelly
Oct 31, 2012·Psycho-oncology·Marleen J J PullensJan A Roukema
Apr 5, 2014·Psycho-oncology·Jin-Shei LaiDavid Cella
Aug 5, 2015·Journal of Cancer Survivorship : Research and Practice·John E SchmidtRuth Rechis
Jun 13, 2015·Journal of the National Cancer Institute. Monographs·Kerstin Hermelink
Jun 5, 2012·Cancer Treatment Reviews·Amanda D HutchinsonCarlene Wilson
Nov 1, 2011·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Birgitte Goldschmidt MertzNiels Kroman
Jun 1, 2011·Asian Nursing Research·Seongmi MoonMi-Ja Kim
Mar 19, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jochen KaiserJörg Dietrich
Jul 1, 2014·Menopause : the Journal of the North American Menopause Society·Florien W BoeleSanne B Schagen
Nov 1, 2012·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·P FrémontP Rischmann
Nov 12, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mi Sook Jung, Moira Visovatti
Dec 11, 2014·Revista latino-americana de enfermagem·Bianca Fresche de SouzaAdriana Inocenti Miasso
Jan 20, 2017·Brain Imaging and Behavior·Thibo BillietSabine Deprez
Apr 9, 2011·Nature Reviews. Urology·Robert Zachariae, Mimi Yung Mehlsen
Jun 9, 2018·Journal of the International Neuropsychological Society : JINS·Barbara CollinsGiorgio A Tasca
Apr 26, 2012·British Journal of Cancer·K RibiUNKNOWN International Breast Cancer Study Group

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