Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
María Gracia CalettiMabel Missoni

Abstract

Renal disease is the most important long-term complication of hemolytic-uremic syndrome (HUS). A comparative study of renal function was carried out in two groups of patients. Group 1 included 19 children followed for a median of 11 years, 1960-1980, with a low-sodium diet, antihypertensive drugs, and a restricted protein intake in the end stage of renal disease. Group 2 included 26 children treated for a median of 9 years, 1988-2002, on a low-sodium diet, early restriction of protein intake according to recommendations, and angiotensin converting enzyme inhibitors (ACEi). Long-term renal function was assessed by the inverse of the plasma creatinine concentration (1/[Cr]) over time. Linear regression lines were fitted to individual values of 1/[Cr] for each child. Regression coefficients of children in group 1 were all negative, ranging from -0.031 to -0.00043; 7 were significantly different from zero, indicating a linear fall in renal function over time. In contrast, children from group 2 had 11 negative slopes (only 1 significant) and 15 positive slopes, ranging from 0.17893 to -0.3899. Fisher's exact test showed that group 1 had significantly more children with negative slopes than group 2. This comparatively better long-ter...Continue Reading

Citations

Feb 17, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·María Gracia CalettiAdriana Haydeé Roy
May 3, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maria Gracia CalettiStella Maris Rasse
Dec 20, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·María Gracia CalettiClarisa Vezzani
Apr 4, 2006·The Surgical Clinics of North America·Ai-Xuan L HoltermanRuth A Seeler
Apr 1, 2005·Current Opinion in Pediatrics·Richard Siegler, Robert Oakes
Sep 22, 2005·Current Opinion in Critical Care·Jessica CaprioliGiuseppe Remuzzi
Oct 10, 2019·American Journal of Epidemiology·Derek K NgAlvaro Muñoz
Nov 24, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Alejandro BalestracciMaría Gracia Caletti
Jan 25, 2020·Toxins·Adrien JosephAlexandre Hertig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Maria Van Dyck, Willem Proesmans
JAMA : the Journal of the American Medical Association
Howard TrachtmanInvestigators of the HUS-SYNSORB Pk Multicenter Clinical Trial
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Chantal Loirat, Patrick Niaudet
© 2022 Meta ULC. All rights reserved