PMID: 11902888Mar 21, 2002Paper

Two-dimensional (2D) pulsed electron paramagnetic resonance study of VO(2+)-triphosphate interactions: evidence for tridentate triphosphate coordination, and relevance to bone uptake and insulin enhancement by vanadium pharmaceuticals

Journal of the American Chemical Society
Sergei A DikanovChris Orvig

Abstract

Two- and four-pulse electron spin echo envelope modulation (ESEEM) and four-pulse two-dimensional hyperfine sublevel correlation (HYSCORE) spectroscopies have been used to determine the solution structure of a 3:1 triphosphate:vanadyl solution at pH 5.0. Limited quantitative data were extracted from the two pulse spectra; however, HYSCORE proved to be more useful in the detection and interpretation of the (31)P and (1)H couplings. Three sets of cross-peaks were observed for each nucleus. For the (31)P couplings, three sets of cross-peaks were observed in the HYSCORE spectrum, and contour line shape analysis yielded coupling constants of approximately 15, 9, and 1 MHz. HYSCORE cross-peaks in the proton region were partially overlapping; however, interpretation of the proton coupling was simplified through the use of one-dimensional four-pulse ESEEM and subsequent analysis of the sum combination peaks. Comparison of the derived isotropic and anisotropic coupling constants with results from earlier ESEEM and electron nuclear double resonance (ENDOR) studies was consistent with the presence of at least one, and most likely two, water molecules coordinated in the equatorial plane of the vanadyl cation. The vanadyl-triphosphate syste...Continue Reading

References

Nov 27, 1974·Journal of the American Chemical Society·G M WoltermannG P Haight
Feb 1, 1984·Journal of Inorganic Biochemistry·W R HarrisD Silberman
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Citations

May 16, 2014·Molecular Physics·Sergei A DikanovChris Orvig
Mar 21, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jan PetersenDavid J Lowe
Apr 4, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jan PetersenDavid J Lowe
Feb 24, 2016·Future Medicinal Chemistry·Dieter Rehder
Apr 27, 2005·Dalton Transactions : an International Journal of Inorganic Chemistry·Kwan Mook KimWonwoo Nam
Apr 4, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Debbie C CransPeter A Lay
Feb 9, 2008·Inorganic Chemistry·Malin BacklundPatrick J Farmer
Apr 27, 2018·The Journal of Physical Chemistry. B·Sergei A Dikanov, Alexander T Taguchi
Feb 29, 2008·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Xianyong YuZhong Chen
Jun 6, 2003·Journal of the American Chemical Society·Kôichi FukuiHitoshi Michibata
Nov 11, 2003·Inorganic Chemistry·Jana A LewisSeth M Cohen
Feb 24, 2009·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Xianyong YuZhong Chen

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