Two-Dimensional Analysis of Horizontal and Vertical Pursuit in Infantile Nystagmus Reveals Quantitative Deficits in Accuracy and Precision

Investigative Ophthalmology & Visual Science
Lee McilreavyJonathan T Erichsen

Abstract

Infantile nystagmus (IN) presents with continuous, predominantly horizontal eye oscillations. It remains controversial whether those with IN have normal horizontal pursuit, while vertical pursuit has rarely been studied. We examined whether there are pursuit deficits associated with IN by investigating the effect of target direction, velocity, and amplitude. Twelve adults with idiopathic IN performed a pursuit task, a 0.4° dot moved either horizontally or vertically at 8 or 16°/s, through amplitudes of 8°, 16°, or 32°. Accuracy and precision errors were computed as bivariate probability density functions of target-relative eye velocities. Eye velocity was less precise along the horizontal axis during both horizontal and vertical pursuit, reflecting the primary axis of the eye oscillation. Mean accuracy error along the target trajectory during vertical pursuit was just as impaired as during horizontal pursuit. There was a greater error in accuracy along the target trajectory for 16°/s targets than 8°/s. Finally, targets that oscillated at 2.0 Hz had a greater error in accuracy along the target trajectory than frequencies of 1.0 Hz or 0.5 Hz. When studied using the same experimental protocol, pursuit performance for typical obser...Continue Reading

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R J Staneloni, L F Leloir
Jan 1, 1992·Documenta Ophthalmologica. Advances in Ophthalmology·L F Dell'OssoH Collewijn
Jan 1, 1992·Documenta Ophthalmologica. Advances in Ophthalmology·L F Dell'OssoH Collewijn
Aug 1, 1991·The Journal of Physiology·G R Barnes, P T Asselman
Feb 1, 1991·Archives of Ophthalmology·R V Abadi, J Whittle
Jun 1, 1988·Perception & Psychophysics·M T Swanston, N J Wade
Mar 1, 1985·Brain : a Journal of Neurology·H CollewijnH Spekreijse
Nov 1, 1974·Archives of Ophthalmology·L F Dell'OssoR B Daroff
Jan 1, 1972·American Journal of Optometry and Archives of American Academy of Optometry·L Dell'OssoL Stark
Dec 1, 1980·The British Journal of Ophthalmology·R D YeeV Honrubia
Aug 4, 1999·Brain : a Journal of Neurology·T Haarmeier, P Thier
Apr 9, 2002·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·L Averbuch-HellerJ S Stahl
Sep 18, 2002·The British Journal of Ophthalmology·R V Abadi, A Bjerre
May 22, 2009·Investigative Ophthalmology & Visual Science·Nagini SarvananthanIrene Gottlob
Oct 21, 2009·Experimental Brain Research·Andrew J KolarikTom C A Freeman
Apr 21, 2012·The British Journal of Ophthalmology·Rebecca Jane McLeanIrene Gottlob
Jun 26, 2012·Journal of Vision·Claudia ChericiMichele Rucci
Feb 15, 2014·JAMA Ophthalmology·Michael C Brodsky, Louis F Dell'Osso
Jun 1, 1999·Behavioural Processes·J C DarchevilleY Miossec
Dec 23, 2016·Journal of Vision·Natela ShanidzePreeti Verghese
Jun 14, 2017·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Valldeflors Vinuela-NavarroJ Margaret Woodhouse
Aug 15, 2018·Frontiers in Neurology·Takao ImaiHidenori Inohara
Mar 16, 2019·Behavior Research Methods·Matt J DunnJonathan T Erichsen
Oct 8, 2019·Translational Vision Science & Technology·Lee McilreavyJonathan T Erichsen

❮ Previous
Next ❯

Software Mentioned

MATLAB
JASP
OpenGL
Delphi

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.