Two-dimensional FeP@C nanosheets as a robust oxidase mimic for fluorescence detection of cysteine and Cu2.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Chan SongCheng Yao

Abstract

In the past few years, the development of novel nanozymes with excellent performance has attracted increasing attention in biosensing. However, most of those nanozymes were found to possess peroxidase activity with the prerequisite of the presence of H2O2. In contrast, oxidase mimics can catalyze the oxidation of substrates without H2O2, delivering a higher signal-to-noise ratio than that of peroxidase mimics in practical applications. Herein, for the first time, two-dimensional (2D) nanosheets composed of iron phosphide embedded in a carbon matrix (FeP@C nanosheets) were found to demonstrate a robust oxidase-like property, different from those previously reported peroxidase mimics based on transition metal phosphides (TMPs). Based on this intriguing observation, the fluorescent substrate Amplex Red (AR) of peroxidase can be effectively oxidized by FeP@C nanosheets in the absence of H2O2. Benefiting from the oxidase-like enzymatic activity of the FeP@C nanosheets, a novel fluorescence sensing platform was developed for the detection of cysteine (Cys) and Cu2+. The outstanding performance of the 2D FeP@C nanosheets endows the proposed platform with superior sensitivity and selectivity compared to many previously reported approac...Continue Reading

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Citations

Oct 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bin LiuGang Wei

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Methods Mentioned

BETA
biosensors
biosensing
X-ray
thermal treatment
atomic force microscopy
fluorescence assay
Fluorescence

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