PMID: 6159809Jan 1, 1980Paper

Two-dimensional gel electrophoresis of sheep plasma proteins: genetic polymorphism of an alphal-protease inhibitor and a post-transferrin

Animal Blood Groups and Biochemical Genetics
R K Juneja, B Gahne

Abstract

Two-dimensional electrophoretic analysis of sheep plasma proteins was performed by a first-dimension separation in agarose gel (pH 5.0) followed by a second-dimension one in horizontal polyacrylamide gel (pH 9.0). This method resulted in improved and reproducible separation of many alpha- and beta-globulins. Two groups of alpha 1-globulins, designated Pi-1 and Pi-2, were found to be protease inhibitors. These two inhibitors differed from each other in protease inhibitory spectra. Genetic polymorphism was observed for the Pi-2 protein and another unidentified protein, tentatively designated as post-transferrin (Ptf). Family data supported the hypothesis that Pi-2 and Ptf types were controlled by codominant, autosomal alleles. Three Pi-2 alleles and two Ptf alleles were observed in one population of the Gotland breed of sheep. The analysis of data from 50 informative matings showed no evidence of genetic linkage between the Pi-2, Ptf and transferrin (Tf) loci in the population of sheep studied.

References

Jun 1, 1978·Genetical Research·D Iannelli
Jan 1, 1979·Animal Blood Groups and Biochemical Genetics·R K JunejaK Sandberg
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B G Johansson
May 1, 1967·Archives of Biochemistry and Biophysics·J C Robinson, G Lee
Sep 1, 1967·Vox Sanguinis·E M TuckerC Stormont

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Citations

Jan 1, 1992·Animal Genetics·M Zurkowski, J Kuryl
Jan 1, 1983·Animal Blood Groups and Biochemical Genetics·J Kurył, J Gasparska
Jan 1, 1980·Animal Blood Groups and Biochemical Genetics·R K Juneja, B Gahne
Jan 1, 1983·Animal Blood Groups and Biochemical Genetics·C M McCoubreyA L Archibald
May 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A StratilY Bouquet
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S D Patterson
Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A DubinA Koj
Nov 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A StratilR Pokorný

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