PMID: 6172538Jan 1, 1982Paper

Two distinct allotypic determinants on the antigen-specific suppressor and enhancing T cell factors that are encoded by genes linked to the immunoglobulin heavy chain locus

The Journal of Experimental Medicine
T Tokuhisa, M Taniguchi

Abstract

The alloantiserum was raised in BALB/c (H-2d, Igh-1a) mice hyperimmunized with spleen cells of Igh allotype congenic mice, CB-20 (H-2d, Igh-1b). It was found to define the new allotypic determinants (distinct from B cell Igh constant region determinants: Igh allotype) expressed only on a small population of T cells belonging to the Thy-1 dull-stained Lyt-2- or Lyt-2+ population of Igh-1b mice. Genes coding for the determinants were shown to be accommodated somewhere in the right side of the Igh variable region gene (Igh-V) cluster, as the antibody activity was completely absorbed with BAB-14 thymocytes. It was also demonstrated that the products detected by the antiserum represent the allotypic determinants (probably constant region determinants) on the antigen-binding moiety of the antigen-specific augmenting (TaF) and suppressor (TsF) T cell factors. Moreover, determinants on TsF were found to be distinct from those on TaF. Therefore, it can be suggested that the two genes coding for the T cell allodeterminants (distinct from those of the B cell Igh) are located in the right side of the B cell Igh-V on the 12th chromosome, and that both encode the antigen-recognition units of the functionally distinct T cell factors.

References

Dec 1, 1979·European Journal of Immunology·F L OwenP D Gottlieb
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg

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Citations

Jan 1, 1982·Immunogenetics·M SuzanB Rubin
Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Oct 1, 1989·Immunology Today·D R WebbC M Sorensen
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J J MarchalonisA C Wang
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K NakanishiT Kishimoto
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S MiyataniT Tada
Sep 1, 1982·The Journal of Experimental Medicine·T TokuhisaM Taniguchi
Jul 1, 1983·The Journal of Experimental Medicine·M KronenbergL Hood
Jan 1, 1982·Immunological Reviews·Y J Rosenberg
Jan 1, 1983·Immunological Reviews·P MarrackJ Kappler
Feb 2, 1984·Nature·F R Blattner, P W Tucker

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