PMID: 2123029Nov 11, 1990Paper

Two distinct immunoglobulin heavy chain isotypes in a primitive, cartilaginous fish, Raja erinacea

Nucleic Acids Research
F A HardingG W Litman

Abstract

Immunoglobulin heavy chain genes in Raja erinacea (little skate) are organized in clusters consisting of VH, DH, JH segments and CH exons (1). An immunoglobulin heavy chain mu-like isotype that exhibits 61-91% nucleotide sequence identity in coding segments to the Heterodontus francisci (horned shark) mu-type immunoglobulin is described. The overall length of the mu-type clusters is approximately 16 kb; transmembrane exons (TM1 and TM2) are located 3 to CH exon 4 (CH4). In three of four TM-containing genomic clones, a significant deletion is present in TM1. A second isotype of Raja immunoglobulin heavy chain genes has been detected by screening a spleen cDNA library with homologous Raja VH- and CH1-specific probes complementing the respective regions of the mu-like isotype. Weak hybridization with VH-specific probes and no discernable hybridization with C mu-specific probes were considered presumptive evidence for a second immunoglobulin isotype that nominally is designated as X-type. The Vx region of the X-type cDNA is approximately 60% identical at the nucleotide (nt) level to other Raja VH segments and thus represents a second VH family. Putative Dx and Jx sequences also have been identified. The constant region of the X-typ...Continue Reading

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Citations

Jan 1, 1995·Developmental and Comparative Immunology·G W Warr
Mar 1, 1995·Developmental and Comparative Immunology·M R WilsonG W Warr
Sep 1, 1992·Molecular Immunology·M VazquezM Kasahara
May 1, 1996·Research in Immunology·E Andersson, T Matsunaga
Apr 1, 1993·Current Opinion in Immunology·L Du Pasquier
Sep 5, 2002·Nature Reviews. Immunology·Martin F Flajnik
Dec 1, 1994·Nature Structural Biology·S BarréC Chothia
Aug 14, 1999·Scandinavian Journal of Immunology·I HordvikB Krossøy
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C T AmemiyaG W Litman
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·J P Rast, G W Litman
Jun 1, 1993·Avian Pathology : Journal of the W.V.P.A·D A Higgins, G W Warr
Jun 8, 1999·Annual Review of Immunology·G W LitmanJ P Rast
Jun 17, 2011·BMC Evolutionary Biology·Susana Magadán-MompóFrancisco Gambón-Deza
May 11, 2004·BMC Immunology·Lynn L RumfeltMartin F Flajnik
Aug 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yaofeng ZhaoLennart Hammarström
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Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·L L RumfeltM F Flajnik
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Nov 24, 2016·Biology·Sara Mashoof, Michael F Criscitiello

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