Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases.

Seminars in Immunopathology
Motohiro KobayashiMinoru Fukuda

Abstract

Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin α4β7 ligand mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expressed on high endothelial venules (HEVs) and HEV-like vessels. In this review, we discuss these two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases with reference to our and others' previously published works. We also describe a recently developed recombinant integrin α4β7 heterodimeric IgG chimera that can be used as an immunohistochemical reagent to stain functional MAdCAM-1.

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Citations

Dec 5, 2014·Pathology·Takuma OkamuraMotohiro Kobayashi
Apr 3, 2015·Pathology International·Yasuhiro Sakai, Motohiro Kobayashi
Jan 20, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Shulin LowMotohiro Kobayashi
Jan 16, 2014·The Journal of Biological Chemistry·Mehrab NasirikenariJoseph T Y Lau
Jun 28, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Masatomo KawakuboJun Nakayama
Jun 1, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Manami TsutsumiuchiMotohiro Kobayashi
Oct 16, 2018·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Jinlong FuZhiyong Wang
Jan 28, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natalia Guerra-PérezElena Martinelli

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