PMID: 9188652Jul 1, 1997Paper

Two distinct oncornaviruses harbor an intracytoplasmic tyrosine-based basolateral targeting signal in their viral envelope glycoprotein

Journal of Virology
R LodgeG Lemay

Abstract

It has been clearly established that the budding of the human immunodeficiency virus (HIV-1), a lentivirus, occurs specifically through the basolateral membrane in polarized epithelial cells. More recently, the signal was assigned to a tyrosine-based motif located in the intracytoplasmic domain of the envelope glycoprotein, as previously observed on various other viral and cellular basolateral proteins. In the present study, expression of human T-cell leukemia virus type 1 (HTLV-1) or Moloney murine leukemia virus envelope glycoproteins was used for trans-complementation of an envelope-negative HIV-1. This demonstrated the potential of oncornaviral retrovirus envelope glycoproteins to confer polarized basolateral budding in epithelial Madin-Darby canine kidney cells (MDCK cells). Site-directed mutagenesis confirmed the importance of a common motif encompassing at least one crucial membrane-proximal intracytoplasmic tyrosine residue. The conservation of a similar basolateral maturation signal in different retroviruses further supports its importance in the biology of this group of viruses.

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Citations

Apr 5, 2000·Pathology Oncology Research : POR·J OngrádiM Bendinelli
Jan 15, 2010·Journal of Virology·Katrin SchlieWolfgang Garten
Jan 21, 2011·AIDS Research and Human Retroviruses·Marc C Johnson
Dec 10, 1999·Journal of Virology·S AskovićJ L Portis
Jul 20, 2012·Molecular Biology International·Tsutomu Murakami
May 20, 2011·Journal of Virology·Jing JinWalther Mothes
Dec 17, 2004·Biology of the Cell·Robert S Cohen
Jul 11, 2003·Developmental Cell·Eugenia BasyukEdouard Bertrand

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