Two distinct types of depolarizing afterpotentials are differentially expressed in stellate and pyramidal-like neurons of entorhinal-cortex layer II

Hippocampus
Camilla AlessiJacopo Magistretti

Abstract

Two types of principal neurons, stellate cells and pyramidal-like cells, are found in medial entorhinal-cortex (mEC) layer II, and are believed to represent two distinct channels of information processing and transmission in the entorhinal cortex-hippocampus network. In this study, we found that depolarizing afterpotentials (DAPs) that follow single action potentials (APs) evoked from various levels of holding membrane voltage (Vh ) show distinct properties in the two cells types. In both, an evident DAP followed the AP at near-threshold Vh levels, and was accompanied by an enhancement of excitability and spike-timing precision. This DAP was sensitive to voltage-gated Na(+)-channel block with TTx, but not to partial removal of extracellular Ca(2+). Application of 5-μM anandamide, which inhibited the resurgent and persistent Na(+) -current components in a relatively selective way, significantly reduced the amplitude of this particular DAP while exerting poor effects on the foregoing AP. In the presence of background hyperpolarization, DAPs showed an opposite behavior in the two cell types, as in stellate cells they became even more prominent, whereas in pyramidal-like cells their amplitude was markedly reduced. The DAP observed ...Continue Reading

References

Oct 1, 1976·The Journal of Comparative Neurology·O Steward, S A Scoville
Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Sep 11, 1989·Brain Research·M Kaneda, N Akaike
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Jan 1, 1994·Journal of Neurophysiology·S H ChandlerL J Goldberg
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·L R Squire, S M Zola
Jun 1, 1997·Journal of Neurophysiology·M KobayashiT Morimoto
Aug 15, 1997·Neural Computation·M L Hines, N T Carnevale
May 24, 2000·British Journal of Pharmacology·P EllerJ Striessnig
Oct 13, 2000·The European Journal of Neuroscience·A Urbani, O Belluzzi
Apr 9, 2004·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Wendy A Suzuki, David G Amaral
Jun 21, 2005·Nature·Torkel HaftingEdvard I Moser
Oct 21, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cuiyong YueYoel Yaari
Jul 25, 2008·Journal of Neurophysiology·Michel RoyeckHeinz Beck
Nov 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jun Hee KimHenrique von Gersdorff
Jun 12, 2014·Nature Reviews. Neuroscience·Edvard I MoserMay-Britt Moser

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Citations

Aug 27, 2016·The Journal of Physiology·Christoph HönigspergerJohan F Storm
Jun 21, 2018·Journal of Neurophysiology·Jingliang ZhangZhuo Huang
Aug 15, 2020·Annals of the New York Academy of Sciences·Nupur Katyare, Sujit Kumar Sikdar

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