Two dopamine receptors: supportive evidence with the rat rotational model

European Journal of Pharmacology
N C TyeI A Pullar

Abstract

Di-isobutyryl apomorphine (5 mg/kg i.p.) and lergotrile (5 mg/kg i.p.) produce long lasting turning behaviour in rats with 6-hydroxydopamine lesions at the level of the substantia nigra. Haloperidol (1.5 and 3.0 mg/kg p.o.) blocks the rotational behaviour due to the apomorphine ester but has no effect on lergotrile turning. Clozapine (10 and 20 mg/kg p.o.) blocks the lergotrile turning but stimulates the rotational behaviour produced by the apomorphine ester. The results support the concept of two anatomically separate dopamine receptors and their relevance to the study of antipsychotic activity is discussed.

Citations

Jan 1, 1980·Psychopharmacology·G Gianutsos, K E Moore
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·J N Joyce
Jan 1, 1981·Pharmacology & Therapeutics·E K Silbergeld, D B Calne
Jan 1, 1978·General Pharmacology·J DankovaL J Poirier
Jan 1, 1980·Neuroscience·C J Pycock
Jan 1, 1979·Psychoneuroendocrinology·D P van Kammen
Aug 1, 1979·Behavioral and Neural Biology·L L Hernández, J B Appel
Dec 1, 1979·The Journal of Pharmacy and Pharmacology·A F Sved, J D Fernstrom

Related Concepts

Metazoa
Apokinon
Acceptance Processes
Leponex
Lentiform Nucleus Structure
Intropin
Ergoline
Haldol
Limbic System
Dopamine Receptor

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