Two-dose emtricitabine/tenofovir alafenamide plus bictegravir prophylaxis protects macaques against SHIV infection.

The Journal of Antimicrobial Chemotherapy
Elena BekermanChristian Callebaut

Abstract

Current prophylaxis options for people at risk for HIV infection include two US FDA-approved daily pre-exposure prophylaxis (PrEP) regimens and guidelines for a 2-1-1 event-driven course specifically for men who have sex with men. Despite this, PrEP use rates remain suboptimal, and additional PrEP options may help to improve uptake among diverse populations. Here, we evaluated protective efficacy of two-dose PrEP and two-dose postexposure prophylaxis (PEP) schedules with emtricitabine (FTC)/tenofovir alafenamide (TAF) with or without bictegravir (BIC) in an SHIV macaque model. Macaques received one oral dose of 200 mg emtricitabine, 25 mg tenofovir alafenamide and 25-100 mg of bictegravir to establish pharmacokinetic profiles of each drug either in the plasma or the peripheral blood mononuclear cells. Protective efficacy of multiple two-dose PrEP and PEP schedules with FTC/TAF with or without bictegravir was then assessed in two repeat low-dose rectal SHIV challenge studies. The data revealed over 95% per-exposure risk reduction with FTC/TAF PrEP initiated 2 h before the exposure, but a loss of significant protection with treatment initiation postexposure. In contrast, FTC/TAF plus BIC offered complete protection as PrEP and gr...Continue Reading

References

Apr 8, 2010·Science Translational Medicine·J Gerardo García-LermaWalid Heneine
Nov 26, 2010·The New England Journal of Medicine·Robert M GrantUNKNOWN iPrEx Study Team
Jul 13, 2012·The New England Journal of Medicine·Jared M BaetenUNKNOWN Partners PrEP Study Team
Sep 12, 2012·Current Opinion in HIV and AIDS·J Gerardo García-Lerma, Walid Heneine
Jun 19, 2015·PLoS Pathogens·Mowgli HolmesPaul D Bieniasz
Dec 2, 2015·The New England Journal of Medicine·Jean-Michel MolinaUNKNOWN ANRS IPERGAY Study Group
Apr 4, 2017·The Journal of Antimicrobial Chemotherapy·Mackenzie L CottrellAngela D M Kashuba
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julia L MarcusJonathan E Volk
Nov 4, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susan ScheerNancy A Hessol
Jan 6, 2018·Journal of General Internal Medicine·Misha HuangMary T Bessesen
Oct 22, 2018·The Lancet. HIV·Andrew E GrulichUNKNOWN Expanded PrEP Implementation in Communities New South Wales (EPIC-NSW) research group
Feb 8, 2019·JAMA : the Journal of the American Medical Association·Anthony S FauciBrett P Giroir

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Citations

May 20, 2021·The Journal of Antimicrobial Chemotherapy·Richard E HaalandWalid Heneine

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Methods Mentioned

BETA
PCR

Software Mentioned

TAQMAN
SAS
IPERGAY
GraphPad Prism

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