Two-dose epoetin alfa reduces blood transfusions compared with autologous donation

Clinical Orthopaedics and Related Research
Mary E HardwickClifford W Colwell

Abstract

This study evaluated whether patients receiving a two-dose regime of epoetin alfa received less allogeneic blood than patients donating autologous blood before primary hip arthroplasty. Consenting patients with a hemoglobin level between 12 and 15 g/dL were randomly assigned to a two-dose administration of epoetin alfa (19 patients) or autologous donation (21 patients). Sixteen percent of the patients in the epoetin alfa group and 52% of the patients in the autologous donation group received transfusions, with a mean volume of 90 cc per patient in the epoetin alfa group and 340 cc in the autologous donation group. Hemoglobin was similar at screening; however, the epoetin alfa group achieved a higher hemoglobin (14.6 g/dL) than the autologous donation group (12.6 g/dL) before surgery. Hemoglobin remained significantly higher in the epoetin alfa group for 3 days after surgery. Administration of two doses of epoetin alfa provided patients with effective and safe reduction of allogeneic blood transfusions and decreased the necessity and difficulty of autologous donation before total hip arthroplasty.

References

Jun 1, 1997·Clinical Orthopaedics and Related Research·C S OishiC W Colwell
Jan 26, 1999·Clinical Orthopaedics and Related Research·R K Spence
Jul 20, 2000·The Journal of Bone and Joint Surgery. American Volume·D GrosvenorS Goodman

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Citations

Dec 20, 2014·Clinical Orthopaedics and Related Research·Chris A AnthonyCarolyn M Hettrich
Sep 3, 2011·European Journal of Anaesthesiology·Stefan De HertUNKNOWN Task Force on Preoperative Evaluation of the Adult Noncardiac Surgery Patient of the European Society of Anaesthesiology
Jan 5, 2014·Clinical Orthopaedics and Related Research·Chih-Hsiang ChangMel S Lee
Jul 4, 2012·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Stephen KimFriedrich Boettner
Jan 7, 2016·The Bone & Joint Journal·E P Su, S Su
Aug 12, 2014·Clinical Orthopaedics and Related Research·Hany BedairJoseph C McCarthy
Sep 22, 2007·American Journal of Physical Medicine & Rehabilitation·Heather K Vincent, Kevin R Vincent
Dec 8, 2009·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Friedrich BoettnerThomas P Sculco
Sep 4, 2007·Clinical Orthopaedics and Related Research·Clifford W ColwellJavad Parvizi
May 11, 2021·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Filippo MiglioriniMarcel Betsch

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